The possible hepatoprotective effect of apricot against acrylamide induced hepatotoxicity in rats

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dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorŞahin, Nurhan
dc.contributor.authorTürköz, Yusuf
dc.contributor.authorYılmaz, İsmet
dc.contributor.authorÇınar, Kamuran
dc.contributor.authorAkgöz, Müslüm
dc.contributor.authorCiğremiş, Yılmaz
dc.date.accessioned2018-09-18T12:48:39Z
dc.date.available2018-09-18T12:48:39Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract Objective: The aim of this study was to investigate the possible toxic effects of sub-chronic doses of acrylamide taken with drinking water on liver tissue and to test the preventive role of 5% organic dried apricot as diet supplement, in female Sprague Dawley rats. Materials and Methods: Forty female Spraque Dawley rats were divided into 4 equal groups as follows: control group (C) animals were fed with normal rat chow and tap water, apricot group (A) animals were fed with chow contain %5 apricot and tap water, acrylamide group (AA) animals were fed with normal rat chow and acrylamide at approximately 500 ?g/kg/day via tap water, acrylamide+apricot group (AA+A) animals were fed with chow contain 5% apricot and approximately 500 ?g/kg/day acrylamide via drinking water. The study procedure was maintained during 12 weeks experiment period. At the end of the study, samples of liver tissue were collected for biochemical, histopathological and molecular analyses. Results: In this study, comparison of acrylamide group liver tissue GSH levels and GSH-Px activities were found lower when compared to the control group (p < 0.05). There were no significant differences between the groups based on GST activity, histopathological results and GST-Pi gene expression mRNA levels (p < 0.05). Conclusion: It could be stated that acrylamide, at approximately 500 ?g/kg/day, ingested by rats were detoxified by the liver without resulting any liver tissue damage and application of acrylamide with sun-dried organic apricot did not change any significant molecular, histopathological and biochemical parameters in the liver. Keywords: Acrylamide; Apricot; Antioxidant Enzymes; GST-Pi; Liver.en_US
dc.identifier.citationMehmet Erman E., Nurhan S., Yusuf T., Ismet Y., Kamuran C., Muslum A., Yilmaz C. The possible hepatoprotective effect of apricot against acrylamide induced hepatotoxicity in rats. J Turgut Ozal Med Cent 2017;24(1):48-53.en_US
dc.identifier.doi10.5455/jtomc.2016.12.125en_US
dc.identifier.endpage53en_US
dc.identifier.issn1300-1744
dc.identifier.issue1en_US
dc.identifier.startpage48en_US
dc.identifier.trdizinid284885en_US
dc.identifier.urihttps://doi.org/10.5455/jtomc.2016.12.125
dc.identifier.urihttps://hdl.handle.net/11616/8974
dc.identifier.urihttp://www.totmdergisi.org/articles/2017/volume24/issue1/2017_24_1_10.pdf
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/284885
dc.identifier.volume24en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTurgut Özal Tıp Merkezi Dergisien_US
dc.relation.ispartofTurgut Özal Tıp Merkezi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcrylamideen_US
dc.titleThe possible hepatoprotective effect of apricot against acrylamide induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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