Paricalcitol inhibits the Wnt/beta-catenin signaling pathway and ameliorates experimentally induced arthritis

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dc.authoridYolbaş, Servet/0000-0001-8516-9769
dc.authoridAKIN, Mehmet/0000-0003-0776-7653
dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authoridCelik, Zulfinaz Betul/0000-0003-1390-7309
dc.authoridTektemur, Ahmet/0000-0002-2476-0413
dc.authoridKoca, Suleyman Serdar/0000-0003-4995-430X
dc.authoridYILDIRIM, AHMET/0000-0002-8810-1302
dc.authorwosidYolbaş, Servet/ABI-5312-2020
dc.authorwosidTektemur, Ahmet/V-8755-2018
dc.authorwosidAKIN, Mehmet/AAU-1811-2021
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.contributor.authorYolbas, Servet
dc.contributor.authorYildirim, Ahmet
dc.contributor.authorTektemur, Ahmet
dc.contributor.authorCelik, Zulfinaz Betul
dc.contributor.authorOnalan Etem, Ebru
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.contributor.authorAkin, Mehmet Mustafa
dc.date.accessioned2024-08-04T20:09:57Z
dc.date.available2024-08-04T20:09:57Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aim: The Wnt/beta-catenin pathway has important biological activities, including the differentiation of cells and joint formations. The aim of our study was to determine the effect of paricalcitol on experimentally induced arthritis. Materials and methods: Type II collagen combined with Freund's adjuvant was applied to induce arthritis in Wistar albino female rats. Paricalcitol (0.3 mu g/kg daily) was subcutaneously injected starting 1 day after collagen applications (prophylactic group) or 1 day after the onset of arthritis (therapeutic group), until day 29. Results: The 29th day arthritis scores were lower compared to the 13th day scores in the paricalcitol groups (P < 0.05), while they were higher in the arthritis group (P < 0.05). Marked cartilage-bone destruction and extensive perisynovial inflammation were detected in the arthritis group. Decreased cartilage-bone destruction and perisynovial inflammation in the paws were observed in the paricalcitol groups. The tissue mRNA levels of DKK1, Wnt5a, and axin-2 were higher in the arthritis group than in the control group. In the paricalcitol groups, mRNA expressions were lower than in the arthritis group. Conclusion: The present study shows that the Wnt/beta-catenin signaling pathway is active in arthritis. Moreover, paricalcitol ameliorates arthritis via inhibiting the Wnt/beta B-catenin pathway. Paricalcitol and the Wnt/beta-catenin pathway are candidates for research in human rheumatoid arthritis.en_US
dc.identifier.doi10.3906/sag-1804-62
dc.identifier.endpage1086en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.pmid30384579en_US
dc.identifier.scopus2-s2.0-85055903270en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1080en_US
dc.identifier.trdizinid299608en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1804-62
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/299608
dc.identifier.urihttps://hdl.handle.net/11616/92514
dc.identifier.volume48en_US
dc.identifier.wosWOS:000452889200028en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectWnt/beta-catenin signaling pathwayen_US
dc.subjectparicalcitolen_US
dc.titleParicalcitol inhibits the Wnt/beta-catenin signaling pathway and ameliorates experimentally induced arthritisen_US
dc.typeArticleen_US

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