Genotoxic effects of tacrolimus on human lymphocyte cells

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dc.authoridKURTOĞLU, Elçin Latife/0000-0002-8375-8399
dc.authoridYuksel, Sengul/0000-0002-7190-431X
dc.authorwosidKURTOĞLU, Elçin Latife/AAQ-6842-2020
dc.authorwosidASLAN, Elçin Latife/A-3923-2017
dc.authorwosidYuksel, Sengul/ABI-2182-2020
dc.contributor.authorKurtoglu, E. L.
dc.contributor.authorYuksel, S.
dc.date.accessioned2024-08-04T20:35:56Z
dc.date.available2024-08-04T20:35:56Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe designed in vitro study to determine possible genotoxic effects of tacrolimus (FK-506), which is used as a potent immunosuppressive drug, by using sister chromatid exchange (SCEs), chromosome aberration (CAs), micronuclei tests (MN) and cell growth kinetics such as mitotic index (MI) and replication index (RI) in human lymphocytes. The ceils were treated with 5, 25, 50, and 100 ng/ml concentrations of tacrolimus, for 24 and 48 h treatment periods. Tacrolimus induced CA and MN frequency at all concentrations for 24 and 48 h. In additon, it induced the SCE at the highest concentration for 24 h and at 25 and 100 ng/ml for 48 h. Tacrolimus decreased MI at all concentrations (except 5 ng/ml) for all treatment periods. It also inhibited the RI at 50 and 100 ng/ml concentrations for 24 h and at all concentrations for 48 h. Treatments given with tacrolimus result in the enhance of the different endpoints of genotoxicity, suggesting its mutagenic action on lymphocytes in vitro.en_US
dc.description.sponsorshipInonu University [2008/69]en_US
dc.description.sponsorshipThis study was funded by Inonu University Research Fund (2008/69).en_US
dc.identifier.doi10.1134/S1022795412050134
dc.identifier.endpage655en_US
dc.identifier.issn1022-7954
dc.identifier.issn1608-3369
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84862317485en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage651en_US
dc.identifier.urihttps://doi.org/10.1134/S1022795412050134
dc.identifier.urihttps://hdl.handle.net/11616/95686
dc.identifier.volume48en_US
dc.identifier.wosWOS:000305228100010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMaik Nauka/Interperiodica/Springeren_US
dc.relation.ispartofRussian Journal of Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRenal-Transplantationen_US
dc.subjectChromosomal-Aberrationsen_US
dc.subjectImmunosuppressive Drugsen_US
dc.subjectCyclosporine-Aen_US
dc.subjectFk-506en_US
dc.subjectMutagenicityen_US
dc.subjectCarcinogensen_US
dc.subjectRecipientsen_US
dc.subjectCanceren_US
dc.subjectAssayen_US
dc.titleGenotoxic effects of tacrolimus on human lymphocyte cellsen_US
dc.typeArticleen_US

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