Influence of N-acetyl-5-methoxytryptamine on Fetal Lung Maturation in Experimental Preterm Delivery Model

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridULAS, MUSTAFA/0000-0003-2310-7567
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidULAS, MUSTAFA/W-6684-2018
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorCelik, Onder
dc.contributor.authorHascalik, Seyma
dc.contributor.authorTamser, Mustafa
dc.contributor.authorKirimliolu, Hale
dc.contributor.authorGuven, M. Atahan
dc.contributor.authorDogru, M. Ilker
dc.contributor.authorDogru, A. Kocagun
dc.date.accessioned2024-08-04T20:09:46Z
dc.date.available2024-08-04T20:09:46Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The study was planned to investigate the effect of pharmacological concentrations of melatonin on maturation of the fetal lung in preterm delivered rats. Materials and Methods: Thirty pregnant rats were divided into three groups. The study group received either betametasone (n=10) or melatonin (n=10) between 17th and 18th days of gestation, whereas the third group (n=10) served as control. Pregnancies were terminated on the 21st days of gestation in the control group and on the 19th days of gestation in the betametasone and melatonin groups. Amniotic fluid adrenomedullin, nitric oxide (NO) concentrations and lamellar body count were determined and results compared with each other. Results: The adrenomedullin levels of the melatonin, betametasone and control groups were found to be 29.84 +/- 3.45 pg/ml, 43.15 +/- 6.63 pg/ml and 49.39 +/- 12.93 pg/ml, respectively. The mean lamellar body count was found to be five fold higher in the control group than that in the melatonin group; and, it was 4.1 fold higher in the betametasone group than that in the melatonin group. There were no significant difference among the groups regarding the NO levels. Lamellar body counts of the betametasone and control groups were higher than those which have received melatonin, but the difference was not statistically significant (p>0.05). Masson's trichrome stained section were similar in all groups. Discussion: Melatonin was found to maintain the 19th day amniotic fluid adrenomedullin, lamellar body and NO levels within the 21st day limits. It is possible that adrenomedullin secretion was modulated by exogenous melatonin administration and melatonin may have been involved in the regulation of fetal lung maturation.en_US
dc.identifier.endpage355en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-38649121430en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage350en_US
dc.identifier.trdizinid82762en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/82762
dc.identifier.urihttps://hdl.handle.net/11616/92400
dc.identifier.volume8en_US
dc.identifier.wosWOS:000420591600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal of The Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfetal lung maturationen_US
dc.subjectmelatoninen_US
dc.subjectbetametasoneen_US
dc.subjectadrenomedullinen_US
dc.subjectNOen_US
dc.subjectlamellar bodyen_US
dc.titleInfluence of N-acetyl-5-methoxytryptamine on Fetal Lung Maturation in Experimental Preterm Delivery Modelen_US
dc.typeArticleen_US

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