High expression of CD8 in the tumor microenvironment is associated with PD-1 expression and patient survival in high-grade serous ovarian cancer

Basit Öğe Kaydı
dc.authoridOglak, Süleyman Cemil/0000-0001-7634-3008
dc.authoridAkbayir, Ozgur/0000-0002-2699-4969
dc.authoridSeyhan, Niyazi alper/0000-0003-0543-6180
dc.authoridakgol, sedat/0000-0001-8609-3049
dc.authoridKinter, Alp Koray/0000-0003-3574-6649
dc.authoridOLMEZ, OMER FATIH/0000-0001-7934-7039
dc.authorwosidOglak, Süleyman Cemil/ABE-8344-2022
dc.contributor.authorOlmez, Fatma
dc.contributor.authorOglak, Suleyman Cemil
dc.contributor.authorOlmez, Omer Fatih
dc.contributor.authorAkbayir, Ozgur
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorAkgol, Sedat
dc.contributor.authorKonal, Merve
dc.date.accessioned2024-08-04T20:10:14Z
dc.date.available2024-08-04T20:10:14Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The current study assesss programmed death-1 (PD-1) receptor expression and CD3, CD4, and CD8 tumor-infiltrating lymphocytes (TILs) in high-grade serous ovarian cancer (HGSOC) and to associate our results with neoadjuvant chemotherapy history and disease prognosis. Materials and Methods: We included cases diagnosed with primary HGSOC with biopsy or surgical resection materials in this study. The immunoreactivity of CD3, CD4, CD8, and PD1 was assessed immunohistochemically in tumor tissue. We analyzed TILs in two predetermined groups of high and low TIL. The relationships between clinical characteristics, PD-1, and TIL were assessed. by the chi((2)) test or Fisher's Exact test. We used Kaplan-Meier survival analysis and Cox proportional hazards regression model to the connection between survival and the amounts of TIL, and PD1. Results: Univariate analysis demonstrated that optimal debulking (p<0.001), early International Federation of Gynecology and Obstetrics stage (p=0.046), and higher scores of stromal CD8+ TIL expression (p=0.028) in tumor cells were all substantially correlated with longer disease-free survival (DFS), whereas the remaining variables analyzed, including PD-1 positivity, stromal CD3+, and CD4+ TILs, and intraepithelial CD3+, CD4+, and CD8+ TILs, were not correlated with DFS. Also, univariate analysis revealed that optimal debulking (p=0.010), and higher scores of stromal CD8+ TIL expression (p=0.021) in tumor cells were all substantially correlated with longer overall survival (OS). Conclusion: Higher scores of stromal CD8+ TILs are substantially correlated with DFS and OS in univariate analyses, whereas scores of stromal CD3+ and CD4+ TILs, and intraepithelial CD3+, CD4+, and CD8+ TILs are not correlated with DFS and OS in both univariate and multivariate analyses. Also, we found a significant association between PD-1 positivity and the scores of stromal CD3+ TILs and intraepithelial CD8+ TILs. However, no remarkable relationship was revealed between PD-1 positivity and the survival of HGSOC cases.en_US
dc.identifier.doi10.4274/tjod.galenos.2022.59558
dc.identifier.endpage256en_US
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue3en_US
dc.identifier.pmid36149309en_US
dc.identifier.scopus2-s2.0-85138713069en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage246en_US
dc.identifier.trdizinid1135136en_US
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2022.59558
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1135136
dc.identifier.urihttps://hdl.handle.net/11616/92673
dc.identifier.volume19en_US
dc.identifier.wosWOS:000864321500012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHigh-grade serous ovarian canceren_US
dc.subjectprogrammed death-1 receptoren_US
dc.subjecttumor-infiltrating lymphocytesen_US
dc.titleHigh expression of CD8 in the tumor microenvironment is associated with PD-1 expression and patient survival in high-grade serous ovarian canceren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu