Palladium(II) Complexes with N-Heterocyclic carbene and morpholine ligands: Synthesis, characterization, and their effects on herg1 potassium channel gene expression in the MCF-7 breast cancer cells
Küçük Resim Yok
Tarih
2026
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Acetylphenyl and various fluorinated alkyl-functionalized imidazol-2-ylidene carbene complexes of Pd(II) were prepared by the reaction of dibromo[1-(4-acetylphenyl)-3-(fluorinatedalkyl)imidazole-2-ylidene]pyridinepalladium(II) with morpholine in dichloromethane. The structures of the synthesized complexes were characterized using spectroscopic such as 1H, 13C, 19F NMR, and FT-IR and elemental analysis techniques. The Pd(II) complex 2d, incorporating an N-heterocyclic carbene (NHC) and morpholine ligand, was structurally characterized by Xray crystallography. The crystal packing reveals N-H & ctdot;Br hydrogen bonds, C-H & ctdot;F/O interactions, and C-F & ctdot;it stacking, forming a 3D network stabilized by supramolecular interactions. The cytotoxicity of the synthesized compounds (2a-f) was evaluated using the MCF-7 cell line. The anticancer activity of palladium complexes against MCF-7 cells was revealed with IC50 values ranging from 48.13-151.02 mu M. The effect of complex 2b on the gene expression of the hERG1 K+ channel was determined using the RT-qPCR method. hERG1 potassium channel gene expression decreased at the 50 mu M complex 2b concentration at 24 h.
Açıklama
Anahtar Kelimeler
N -heterocyclic carbene complex, Imidazolium salts, Morpholine, Herg1 k + channel, Gene expression, X-ray crystallography
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
1357
