Palladium(II) Complexes with N-Heterocyclic carbene and morpholine ligands: Synthesis, characterization, and their effects on herg1 potassium channel gene expression in the MCF-7 breast cancer cells

Basit Öğe Kaydı
dc.contributor.authorEroglu, Pelin
dc.contributor.authorGok, Yetkin
dc.contributor.authorIzmirli, Merve
dc.contributor.authorDemirci, Ozlem
dc.contributor.authorKazak, Canan
dc.date.accessioned2026-04-04T13:34:53Z
dc.date.available2026-04-04T13:34:53Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractAcetylphenyl and various fluorinated alkyl-functionalized imidazol-2-ylidene carbene complexes of Pd(II) were prepared by the reaction of dibromo[1-(4-acetylphenyl)-3-(fluorinatedalkyl)imidazole-2-ylidene]pyridinepalladium(II) with morpholine in dichloromethane. The structures of the synthesized complexes were characterized using spectroscopic such as 1H, 13C, 19F NMR, and FT-IR and elemental analysis techniques. The Pd(II) complex 2d, incorporating an N-heterocyclic carbene (NHC) and morpholine ligand, was structurally characterized by Xray crystallography. The crystal packing reveals N-H & ctdot;Br hydrogen bonds, C-H & ctdot;F/O interactions, and C-F & ctdot;it stacking, forming a 3D network stabilized by supramolecular interactions. The cytotoxicity of the synthesized compounds (2a-f) was evaluated using the MCF-7 cell line. The anticancer activity of palladium complexes against MCF-7 cells was revealed with IC50 values ranging from 48.13-151.02 mu M. The effect of complex 2b on the gene expression of the hERG1 K+ channel was determined using the RT-qPCR method. hERG1 potassium channel gene expression decreased at the 50 mu M complex 2b concentration at 24 h.
dc.description.sponsorshipMersin University Scientific Research Project Unit [F279]; Inonu University Research Fund [2017-2-AP3-2645]
dc.description.sponsorshipThe authors gratefully acknowledge Ondokuz May & imath;s University for providing access to the Stoe IPDS II diffractometer, which was funded by the University Research Grant No. F279. This study was financially supported by the Mersin University Scientific Research Project Unit. (2017-2-AP3-2645) . This study was financially supported by the Inonu University Research Fund (FBG-2021-2525) .
dc.identifier.doi10.1016/j.molstruc.2025.145193
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-105026654797
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2025.145193
dc.identifier.urihttps://hdl.handle.net/11616/109472
dc.identifier.volume1357
dc.identifier.wosWOS:001659434000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectN -heterocyclic carbene complex
dc.subjectImidazolium salts
dc.subjectMorpholine
dc.subjectHerg1 k + channel
dc.subjectGene expression
dc.subjectX-ray crystallography
dc.titlePalladium(II) Complexes with N-Heterocyclic carbene and morpholine ligands: Synthesis, characterization, and their effects on herg1 potassium channel gene expression in the MCF-7 breast cancer cells
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu