The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study

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dc.authoridGORKEM, Umit/0000-0002-0848-9731
dc.authoridALADAG, HULYA/0000-0001-7749-3649
dc.authoridTurkler, Can/0000-0003-2716-0322
dc.authoridSimsek, Yavuz/0000-0002-2625-2973
dc.contributor.authorYildirim, Engin
dc.contributor.authorTurkler, Can
dc.contributor.authorGorkem, Umit
dc.contributor.authorSimsek, Omer Yavuz
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorAladag, Hulya
dc.date.accessioned2024-08-04T20:10:09Z
dc.date.available2024-08-04T20:10:09Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Endometrial hyperplasia (EH) is considered an endometrial cancer precursor. This study aimed to determine the role of oxidative stress and thiol groups with antioxidant properties in EH pathogenesis. Materials and Methods: In our prospective case-control study, participants were washed with 5 mL of saline before the endometrial biopsy. Endometrial washing fluid was taken into microtubules, and thiol and disulfide levels were analyzed using the Ellman reagent. Results: A total of 108 patients were in the EH group and 84 patients in the control group. The total and native thiol levels were higher values in the control group (p<0.001, for both). Disulfide levels were higher in the EH group (p<0.001). Native/total thiol ratio and disulfide/total thiol ratio were higher in the EH group (p<0.001, for both). The analysis performed in the control group revealed a significant positive correlation between estradiol and disulfide levels (r=0.322, p=0.033). No significant correlation was found between estradiol and disulfide in the EH group. Conclusion: Oxidative stress level was higher in the washing fluids of patients with EH and this stress plays a role in the EH etiology.en_US
dc.identifier.doi10.4274/tjod.galenos.2021.16132
dc.identifier.endpage303en_US
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue4en_US
dc.identifier.pmid34955009en_US
dc.identifier.scopus2-s2.0-85124337124en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage298en_US
dc.identifier.trdizinid504180en_US
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2021.16132
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/504180
dc.identifier.urihttps://hdl.handle.net/11616/92626
dc.identifier.volume18en_US
dc.identifier.wosWOS:000737881300006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometrial hyperplasiaen_US
dc.subjectoxidative stressen_US
dc.subjectthiolen_US
dc.subjectdisulfideen_US
dc.titleThe relationship between oxidative stress markers and endometrial hyperplasia: A case-control studyen_US
dc.typeArticleen_US

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