The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey

dc.contributor.authorGülbay, Gonca
dc.contributor.authorYesilada, Elif
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorGözükara Bağ, Harika
dc.date.accessioned2021-03-08T06:55:05Z
dc.date.available2021-03-08T06:55:05Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.descriptionDOI: https://doi.org/10.5505/ejm.2020.05945en_US
dc.description.abstractAbstract: Recurrent balanced translocations are generally considered as the main parameter for prognosis in acute myeloid leukemia (AML). In recent years, genetic studies have focused on the ascertaintment of molecular aspects of various oncofusion proteins associated with AML, such as t(15;17) PML-RARA, t(8;21) RUNX1-RUNX1T1, t(9;22) BCR-ABL1 and inv (16) CBFB-MYH11. Therefore, we evaluated AML cases with RT-PCR for known specific genetic abnormalities that could lead to more accurate prognosis. In our study, we retrospectively reviewed the records of 211 cases (59.2% males and 40.8% females). RT-PCR technique was performed to identify t(15;17) PML-RARA, t(8;21) RUNX1-RUNX1T1, t(9;22) BCR-ABL1 and inv (16) CBFBMYH11. The most common rearrangement was found to be t (15; 17) (%12.8) followed by t (8; 21) (7.11%), t (9; 22) (7.6%) and inv (16) (1.42%). Also, in two other cases (0.95%) t(15;17) and t(8;21) were seen together. In addition, none of these rearrangement were found in 148 cases (70.14%) with AML. The presence of chromosomal rearrangements are very important in the diagnosis of AML. Therefore, rapid identification of specific rearrangements during diagnosis is important for prognostic purposes and can help identifying the cause of leukemogenesis and provide new strategies for the treatment of cases. This study is useful for both in Turkey oncologists and transplant centers in other regions will be a reference for the future analyzes and epidemiological data.en_US
dc.identifier.citationGÜLBAY G,YESİLADA E,ERKURT M. A,BAĞ H. G (2020). The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. Eastern Journal of Medicine, 25(3), 350 - 355.en_US
dc.identifier.doi10.5505/ejm.2020.05945en_US
dc.identifier.endpage355en_US
dc.identifier.issn1301-0883
dc.identifier.issn1339-3886
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85089314674en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage350en_US
dc.identifier.trdizinid377206en_US
dc.identifier.urihttps://doi.org/10.5505/ejm.2020.05945
dc.identifier.urihttps://hdl.handle.net/11616/19523
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/377206
dc.identifier.volume25en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofEastern Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkeyen_US
dc.typeArticleen_US

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