XPD and XRCC1 gene polymorphism in patients with normal and abnormal cervical cytology by pap smear.
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The purpose of the present study was to identify the role of abnormalities in DNA repair pathways by measuring the XPD and XRCC1 gene polymorphisms. Thirty-five patients with abnormal cervical cytology (study group) and 10 women with normal cytology (control group) were included in the study. The polymorphisms of XRCC1 Arg194Trp, XRCC1 Arg399Gln and XPD Lys751Gln genes were investigated from the blood samples. There was no statistically significant difference in allele frequencies of XPD gene among the groups (p = 0.097), while XRCC1R399Q gene polymorphism was strikingly more frequent in the study group than that of control cases (p = 0.029). The prevalence of XRCC1R194W gene polymorphism on the other hand, was similar between the groups (p = 0.579). Patients with abnormal and normal cervical cytology have similar XPD gene polymorphism. However, the frequency of gene polymorphism in XRCC1 Arg 399 Gln codon was significantly higher in abnormal cervical cytology group.
Açıklama
Anahtar Kelimeler
DNA binding protein, X-ray repair cross complementing protein 1, xeroderma pigmentosum group D protein, XRCC1 protein, adult, article, case control study, female, gene frequency, genetic predisposition, genetics, human, Human papillomavirus DNA test, methodology, single nucleotide polymorphism, statistics, uterine cervix dysplasia, vagina smear, virology, Adult, Case-Control Studies, DNA-Binding Proteins, Female, Gene Frequency, Genetic Predisposition to Disease, Human Papillomavirus DNA Tests, Humans, Polymorphism, Single Nucleotide, Uterine Cervical Dysplasia, Vaginal Smears, Xeroderma Pigmentosum Group D Protein
Kaynak
European review for medical and pharmacological sciences
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
16
Sayı
12
