XPD and XRCC1 gene polymorphism in patients with normal and abnormal cervical cytology by pap smear.

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dc.authorscopusid55274353300
dc.authorscopusid7004349870
dc.authorscopusid54790841900
dc.authorscopusid24776974100
dc.authorscopusid6603256061
dc.authorscopusid15044572800
dc.authorscopusid6602612326
dc.contributor.authorYilmaz E.
dc.contributor.authorCelik O.
dc.contributor.authorCelik E.
dc.contributor.authorTurkcuoglu I.
dc.contributor.authorSimsek Y.
dc.contributor.authorKaraer A.
dc.contributor.authorOtlu B.
dc.date.accessioned2024-08-04T20:00:49Z
dc.date.available2024-08-04T20:00:49Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of the present study was to identify the role of abnormalities in DNA repair pathways by measuring the XPD and XRCC1 gene polymorphisms. Thirty-five patients with abnormal cervical cytology (study group) and 10 women with normal cytology (control group) were included in the study. The polymorphisms of XRCC1 Arg194Trp, XRCC1 Arg399Gln and XPD Lys751Gln genes were investigated from the blood samples. There was no statistically significant difference in allele frequencies of XPD gene among the groups (p = 0.097), while XRCC1R399Q gene polymorphism was strikingly more frequent in the study group than that of control cases (p = 0.029). The prevalence of XRCC1R194W gene polymorphism on the other hand, was similar between the groups (p = 0.579). Patients with abnormal and normal cervical cytology have similar XPD gene polymorphism. However, the frequency of gene polymorphism in XRCC1 Arg 399 Gln codon was significantly higher in abnormal cervical cytology group.en_US
dc.identifier.endpage1718en_US
dc.identifier.issn1128-3602
dc.identifier.issue12en_US
dc.identifier.pmid23161045en_US
dc.identifier.scopus2-s2.0-84872682053en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1713en_US
dc.identifier.urihttps://hdl.handle.net/11616/91029
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean review for medical and pharmacological sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDNA binding proteinen_US
dc.subjectX-ray repair cross complementing protein 1en_US
dc.subjectxeroderma pigmentosum group D proteinen_US
dc.subjectXRCC1 proteinen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectcase control studyen_US
dc.subjectfemaleen_US
dc.subjectgene frequencyen_US
dc.subjectgenetic predispositionen_US
dc.subjectgeneticsen_US
dc.subjecthumanen_US
dc.subjectHuman papillomavirus DNA testen_US
dc.subjectmethodologyen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectstatisticsen_US
dc.subjectuterine cervix dysplasiaen_US
dc.subjectvagina smearen_US
dc.subjectvirologyen_US
dc.subjectAdulten_US
dc.subjectCase-Control Studiesen_US
dc.subjectDNA-Binding Proteinsen_US
dc.subjectFemaleen_US
dc.subjectGene Frequencyen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectHuman Papillomavirus DNA Testsen_US
dc.subjectHumansen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectUterine Cervical Dysplasiaen_US
dc.subjectVaginal Smearsen_US
dc.subjectXeroderma Pigmentosum Group D Proteinen_US
dc.titleXPD and XRCC1 gene polymorphism in patients with normal and abnormal cervical cytology by pap smear.en_US
dc.typeArticleen_US

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