Voltammetric determination of timolol maleate
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Maik Nauka/Interperiodica
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Timolol as a beta -adrenoceptor antagonist is a potent antihypertensive and antianginal drug, which was also proved to be effective for the secondary prevention of myocardial infarction. The analysis of timolol, as with other oxprenolols, in ophthalmic solutions and biological liquids using sensitive instrumental methods has gained importance. Investigation of the electrochemical behavior of timolol maleate on a mercury drop electrode reveals the presence of a specific reduction peak of analytical significance. Analysis conditions affecting the properties of this peak were optimized by a systematic study. The limit of detection of about 2.5 ppb, obtained for the DPV technique using SMDE, is comparable with the most sensitive techniques. This method is suitable for routine analysis in that it is simpler and requires no preconcentration step for the analysis of therapeutic doses of the drug.
Açıklama
Anahtar Kelimeler
Performance Liquid-Chromatography, Plasma
Kaynak
Journal of Analytical Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
56
Sayı
11
