Voltammetric determination of timolol maleate

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dc.authoridERDOGDU, GAMZE/0000-0002-8114-6946
dc.authorwosid/ABG-9766-2020
dc.authorwosidERDOGDU, GAMZE/ABG-7776-2020
dc.contributor.authorTürkdemir, MH
dc.contributor.authorErdögdu, G
dc.contributor.authorAydemir, T
dc.contributor.authorKaragözler, AA
dc.contributor.authorKaragözler, AE
dc.date.accessioned2024-08-04T20:13:38Z
dc.date.available2024-08-04T20:13:38Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTimolol as a beta -adrenoceptor antagonist is a potent antihypertensive and antianginal drug, which was also proved to be effective for the secondary prevention of myocardial infarction. The analysis of timolol, as with other oxprenolols, in ophthalmic solutions and biological liquids using sensitive instrumental methods has gained importance. Investigation of the electrochemical behavior of timolol maleate on a mercury drop electrode reveals the presence of a specific reduction peak of analytical significance. Analysis conditions affecting the properties of this peak were optimized by a systematic study. The limit of detection of about 2.5 ppb, obtained for the DPV technique using SMDE, is comparable with the most sensitive techniques. This method is suitable for routine analysis in that it is simpler and requires no preconcentration step for the analysis of therapeutic doses of the drug.en_US
dc.identifier.doi10.1023/A:1012565026777
dc.identifier.endpage1050en_US
dc.identifier.issn1061-9348
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-10244229172en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1047en_US
dc.identifier.urihttps://doi.org/10.1023/A:1012565026777
dc.identifier.urihttps://hdl.handle.net/11616/93754
dc.identifier.volume56en_US
dc.identifier.wosWOS:000172177200016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMaik Nauka/Interperiodicaen_US
dc.relation.ispartofJournal of Analytical Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPerformance Liquid-Chromatographyen_US
dc.subjectPlasmaen_US
dc.titleVoltammetric determination of timolol maleateen_US
dc.typeArticleen_US

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