Comparison of primary repair and placing a drain without repair methods in duodenum perforations

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridARSLAN, Ahmet Kadir/0000-0001-8626-9542;
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidARSLAN, Ahmet Kadir/AAA-2409-2020
dc.authorwosidÇevirgen, Furkan/JRW-7495-2023
dc.contributor.authorKaratas, Turgay
dc.contributor.authorKanlioz, Murat
dc.contributor.authorKaratas, Mehmet
dc.contributor.authorGokturk, Nurcan
dc.contributor.authorSelcuk, Engin Burak
dc.contributor.authorCevirgen, Furkan
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-08-04T20:10:20Z
dc.date.available2024-08-04T20:10:20Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: Duodenal ulcer perforation is a serious condition. A number of methods have been defined and used in surgical treatment. In this study, it was aimed to compare the effectiveness of primary repair and drain placement without repair methods in duodenal perforations using an animal model.METHODS: Three equivalent groups of ten rats each were formed. Perforation was created in the duodenum in the first (primary repair/sutured group) and the second group (drain placement without repair/sutureless drainage group). In the first group, the per-foration was repaired with sutures. In the second group, only a drain was placed in the abdomen without sutures. In the third group (control group), only laparotomy was performed. Neutrophil count, sedimentation, serum C-reactive protein (CRP), serum total an-tioxidant capacity (TAC), serum total thiol, serum native thiol, and serum myeloperoxidase (MPO) analyses were performed on animal subjects in the pre-operative period and on the post-operative 1st and 7th days. Histological and immunohistochemical (transforming growth factor-beta 1 [TGF-131]) analyzes were performed. Blood analysis, histological, and immunohistochemical findings obtained from the groups were compared statistically.RESULTS: There was no significant difference between the first and second groups, except for the TAC on the post-operative 7th day and MPO values on the post-operative 1st day (P>0.05). Although tissue healing was more pronounced in the second group than in the first group, there was no significant difference between the groups (P>0.05). TGF-131 immunoreactivity observed in the second group was found to be significantly higher than in the first group (P<0.05). CONCLUSION: We think that the sutureless drainage method is as effective as the primary repair method in the treatment of duo-denal ulcer perforation and can be safely applied as an alternative to the primary repair method. However, further studies are needed to fully determine the efficacy of the sutureless drainage method.en_US
dc.description.sponsorshipInoenue University BAP (Scientific Research Project) unit [TSA-2021-2680]en_US
dc.description.sponsorshipFinancial support for this study was provided by the Inoenue University BAP (Scientific Research Project) unit with the project numbered TSA-2021-2680.en_US
dc.identifier.doi10.14744/tjtes.2023.92324
dc.identifier.endpage654en_US
dc.identifier.issn1306-696X
dc.identifier.issn1307-7945
dc.identifier.issue6en_US
dc.identifier.pmid37278083en_US
dc.identifier.scopus2-s2.0-85160983142en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage647en_US
dc.identifier.trdizinid1190440en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2023.92324
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1190440
dc.identifier.urihttps://hdl.handle.net/11616/92723
dc.identifier.volume29en_US
dc.identifier.wosWOS:001008925000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDuodenal perforationen_US
dc.subjectduodenal perforation drainage treatmenten_US
dc.subjectduodenal ulceren_US
dc.subjectpeptic ulceren_US
dc.subjectsuturing duodenal perforationen_US
dc.titleComparison of primary repair and placing a drain without repair methods in duodenum perforationsen_US
dc.typeArticleen_US

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