Analysis of three outbreaks due to Klebsiella species in a neonatal intensive care unit
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Slack Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: To investigate the clinical, microbiological, and epidemiologic features of three outbreaks caused by Klebsiella during 3 years. SETTING: Neonatal intensive care unit of a university hospital. PATIENTS: Thirty affected neonates. METHODS: Data were collected through chart reviews and conversations with physicians. Screening samples were obtained from the staff, the neonates, and the environment. Antibiogram typing and arbitrarily primed polymerase chain reaction-based fingerprinting were used to type the strains. RESULTS: The first outbreak had 13 K pneumoniae strains isolated. The second outbreak had 10 K. oxytoca strains isolated. The third outbreak had 20 K. pneumoniae strains isolated. More than half of the patients had low birth weights, were premature, and underwent mechanical ventilation and intravenous catheterization. Approximately three-fourths of the patients died. The isolates tested were completely susceptible to meropenem, cefoxitin, and ciprofloxacin and were resistant to cephalothin. More than half of these strains were resistant to many beta-lactam antibiotics, amikacin, and trimethoprim/sulfamethoxazole. Typing procedures yielded 3 antibiotypes and 3 genotypes among the isolates of the first outbreak, 3 antibiotypes with 1 subtype and 2 genotypes with 1 subtype in the second outbreak, and 2 antibiotypes and 2 genotypes in the third outbreak. CONCLUSIONS: Klebsiella outbreaks mainly affected premature neonates with intravenous catheters, mechanical ventilation, or both. The high mortality rate (76.7%) was notable. Resistance to multiple antibiotics, but mainly to broad-spectrum beta-lactam antibiotics, was observed, particularly in K pneumoniae isolates. Molecular typing indicated that the three outbreaks were not related to one other.
Açıklama
2nd Molecular and Diagnostic Microbiology Congress -- APR 21-25, 2002 -- ANTALYA, TURKEY
Anahtar Kelimeler
Spectrum Beta-Lactamases, Typing Methods, Acinetobacter-Baumannii, Resistant Klebsiella, Hospital Outbreak, Pneumoniae, Strain, Enterobacteriaceae, Epidemiology, Infections
Kaynak
Infection Control and Hospital Epidemiology
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
24
Sayı
7
