Analysis of three outbreaks due to Klebsiella species in a neonatal intensive care unit

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dc.authoridaktas, elif/0000-0003-3087-5425
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidaktas, elif/ACL-9792-2022
dc.contributor.authorAyan, M
dc.contributor.authorKuzucu, C
dc.contributor.authorDurmaz, R
dc.contributor.authorAktas, E
dc.contributor.authorCizmeci, Z
dc.date.accessioned2024-08-04T20:13:26Z
dc.date.available2024-08-04T20:13:26Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description2nd Molecular and Diagnostic Microbiology Congress -- APR 21-25, 2002 -- ANTALYA, TURKEYen_US
dc.description.abstractOBJECTIVE: To investigate the clinical, microbiological, and epidemiologic features of three outbreaks caused by Klebsiella during 3 years. SETTING: Neonatal intensive care unit of a university hospital. PATIENTS: Thirty affected neonates. METHODS: Data were collected through chart reviews and conversations with physicians. Screening samples were obtained from the staff, the neonates, and the environment. Antibiogram typing and arbitrarily primed polymerase chain reaction-based fingerprinting were used to type the strains. RESULTS: The first outbreak had 13 K pneumoniae strains isolated. The second outbreak had 10 K. oxytoca strains isolated. The third outbreak had 20 K. pneumoniae strains isolated. More than half of the patients had low birth weights, were premature, and underwent mechanical ventilation and intravenous catheterization. Approximately three-fourths of the patients died. The isolates tested were completely susceptible to meropenem, cefoxitin, and ciprofloxacin and were resistant to cephalothin. More than half of these strains were resistant to many beta-lactam antibiotics, amikacin, and trimethoprim/sulfamethoxazole. Typing procedures yielded 3 antibiotypes and 3 genotypes among the isolates of the first outbreak, 3 antibiotypes with 1 subtype and 2 genotypes with 1 subtype in the second outbreak, and 2 antibiotypes and 2 genotypes in the third outbreak. CONCLUSIONS: Klebsiella outbreaks mainly affected premature neonates with intravenous catheters, mechanical ventilation, or both. The high mortality rate (76.7%) was notable. Resistance to multiple antibiotics, but mainly to broad-spectrum beta-lactam antibiotics, was observed, particularly in K pneumoniae isolates. Molecular typing indicated that the three outbreaks were not related to one other.en_US
dc.identifier.doi10.1086/502245
dc.identifier.endpage500en_US
dc.identifier.issn0899-823X
dc.identifier.issue7en_US
dc.identifier.pmid12887237en_US
dc.identifier.scopus2-s2.0-0042706439en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage495en_US
dc.identifier.urihttps://doi.org/10.1086/502245
dc.identifier.urihttps://hdl.handle.net/11616/93603
dc.identifier.volume24en_US
dc.identifier.wosWOS:000184264100007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSlack Incen_US
dc.relation.ispartofInfection Control and Hospital Epidemiologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpectrum Beta-Lactamasesen_US
dc.subjectTyping Methodsen_US
dc.subjectAcinetobacter-Baumanniien_US
dc.subjectResistant Klebsiellaen_US
dc.subjectHospital Outbreaken_US
dc.subjectPneumoniaeen_US
dc.subjectStrainen_US
dc.subjectEnterobacteriaceaeen_US
dc.subjectEpidemiologyen_US
dc.subjectInfectionsen_US
dc.titleAnalysis of three outbreaks due to Klebsiella species in a neonatal intensive care uniten_US
dc.typeConference Objecten_US

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