The effects of caffeic acid phenethyl ester on cisplatin nephrotoxicity: Increased antioxidant enzyme activity in kidney

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dc.authorscopusid24492292800
dc.authorscopusid6603965905
dc.authorscopusid55903323700
dc.contributor.authorOzbek E.
dc.contributor.authorCekmen M.
dc.contributor.authorTurkoz Y.
dc.date.accessioned2024-08-04T20:02:20Z
dc.date.available2024-08-04T20:02:20Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This article was undertaken to investigate the effect of caffeic acid phenethyl ester (CAPE) on nephropathy and antioxidant enzyme activities in kidneys treated with anticancer agent cisplatin. Design: An experimental study. Material and methods: Twenty four adult male Sprague-Dawley rats were used in our study. The rats were divided into three groups of 8 animals each: Controls (injected with saline, group 1), injected with cisplatin, and injected with cisplatin plus CAPE. Cisplatin was injected intraperitoneally (ip) 5 mg/kg at a single dose (group 2). Group 3 was injected with 5 mg/kg cisplatin single intraperitoneal injection plus CAPE 10 :M/kg/d for 3 days. 24 h after the last injection, rats were sacrificed. Then, kidneys were quickly removed and decapsulated. The renal cortex was carefully separated from the medulla and homogenized. Blood samples were collected to determine the serum levels of urea and creatinine. Crude extracts were used to determine Glutathione Peroxidase (GSH-Px), Catalase (CAT), and Superoxide Dismutase (SOD) activities. Results were compared with Mann-Whitney-U test. Results: Cisplatin administration resulted in a significant decrease of GSH-Px, CAT, and SOD activities in the kidney compared to controls. In the rats treated with cisplatin plus CAPE, there was a remarkable restoration in GSH-Px, CAT, SOD activities (p < 0.05). Conclusions: Our results suggest that cisplatin suppresses SOD, CAT, and GSH-Px activities in the kidney, thereby making the tissue more vulnerable to oxidative stress and peroxidative attacks. These findings also indicate that CAPE given concomitantly with cisplatin could protect the kidney tissue against free radical injury because of antioxidative power of CAPE.en_US
dc.identifier.endpage131en_US
dc.identifier.issn1341-2051
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0033938057en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage129en_US
dc.identifier.urihttps://hdl.handle.net/11616/91610
dc.identifier.volume7en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofInternational Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant enzyme activityen_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectCisplatinen_US
dc.subjectNephrotoxicityen_US
dc.titleThe effects of caffeic acid phenethyl ester on cisplatin nephrotoxicity: Increased antioxidant enzyme activity in kidneyen_US
dc.typeArticleen_US

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