Transplant and non-transplant HCC patients at a single institution

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dc.authoridBASKIRAN, ADIL/0000-0002-7536-1631
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authorwosidBASKIRAN, ADIL/ABI-2356-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorCarr, Brian I.
dc.contributor.authorBag, Harika
dc.contributor.authorInce, Volkan
dc.contributor.authorIsik, Burak
dc.contributor.authorBaskiran, Adil
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:56:08Z
dc.date.available2024-08-04T20:56:08Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aim: Patients with hepatocellular carcinoma (HCC) are managed in various hospital departments, which complicates the assessment of the overall picture. In our large liver transplant institute, we evaluate all HCC patients in a weekly multi -disciplinary liver tumor board, and their data are prospectively collected in an institutional HCC database to evaluate HCC causes, tumor features, treatments, and survival. Materials and Methods: Baseline data for patients (n=1322) were prospectively recorded, including hepatitis status, routine clinical serum parameters, radiological assessment of maximum tumor diameter (MTD), tumor number, presence of macroscopic portal vein thrombosis (PVT), and serum alpha-fetoprotein (AFP) levels. Results: Cirrhosis was found in 81.1% of patients; 58.5% had hepatitis B virus (HBV), 14.9% hepatitis C virus (HCV), 8.9% cryptogenic cirrhosis, and less than 2% had alcoholism. MTD was <5 cm in 61.95% of patients, and 31.9% had PVT. The median overall survival was more than six -fold greater for the 444 liver transplant patients than for those without surgery. Transplanted patients had smaller tumors, whereas larger tumors (MTD >10 cm) were primarily in the no -surgery group. Parallel differences were found for AFP levels (highest in the no -surgery group). PVT was present in similar proportions (25.0% for transplant, 28.0% for no -surgery). The presence of cirrhosis was higher in the transplant group. MTD and levels of serum AFP, gamma-glutamyl transferase (GGT), and blood platelets were prognostic parameters for transplant. Furthermore, AFP and GGT levels were prognostic for transplanted PVT patients. Only albumin was prognostic in the no -surgery patients. Conclusion: Transplanted HCC patients have longer survival, smaller tumors, and more severe liver damage than no -surgery patients. Prognostic subsets were identified within the surgery and the PVT groups.en_US
dc.description.sponsorshipNIH [CA 82723]en_US
dc.description.sponsorshipFinancial Disclosure: This work was supported in part by NIH grant CA 82723 (B.I.C) .en_US
dc.identifier.doi10.14744/hf.2023.2023.0057
dc.identifier.endpage86en_US
dc.identifier.issn1307-5888
dc.identifier.issn2757-7392
dc.identifier.issue2en_US
dc.identifier.pmid38487742en_US
dc.identifier.scopus2-s2.0-85196822026en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.14744/hf.2023.2023.0057
dc.identifier.urihttps://hdl.handle.net/11616/102079
dc.identifier.volume5en_US
dc.identifier.wosWOS:001182619800008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofHepatology Forumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAFPen_US
dc.subjectHCCen_US
dc.subjectmultifocalityen_US
dc.subjectPVTen_US
dc.subjectrelationshipsen_US
dc.titleTransplant and non-transplant HCC patients at a single institutionen_US
dc.typeArticleen_US

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