The protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicity

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorAtes, Burhan
dc.contributor.authorVardi, Nigar
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorKaraaslan, Merve Goksin
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorErcal, Nuran
dc.date.accessioned2024-08-04T20:09:58Z
dc.date.available2024-08-04T20:09:58Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractN-acetylcysteine amide (NACA) is a new antioxidant molecule with powerful radical scavenging properties. The aim of this study was to investigate neuroprotective effects of NACA against paraquat (PQ) toxicity in the midbrains of rats by using motor coordination tests and biochemical and histological analysis. Thirty adult Wistar albino rats were divided into three groups: Group 1: control (n = 10), Group 2: PQ (10 mg/kg) (n = 10), and Group 3: PQ (10 mg/kg) + NACA (100 mg/kg) (n = 10). NACA was administrated intraperitoneally 30 min before PQ injection. Performance was measured for a period of 28 days. The rotarod and accelerod tests were performed prior to and after the experimental period. After the experimental period, rats were sacrificed and midbrain tissues were removed. According to biochemical data, malondialdehyde levels exhibited a significant increase (P < 0.05) when the PQ group was compared to the control group, whereas the NACA-treated group showed a significant decline (P < 0.05). The total glutathione levels (P < 0.01) and the glutathione peroxidase and butyrylcholinesterase activities (P < 0.05) in the NACA treatment group were significantly raised compared with the PQ group. The main finding in the rotarod and accelerod tests was that the PQ + NACA group had improved motor coordination functions, whereas the PQ group had lost motor coordination (P < 0.05). Our histological data were also outstanding and were consistent with biochemical and motor coordination results in terms of the protective role of NACA against PQ-induced neurotoxicity.en_US
dc.description.sponsorshipScientific Research Fund of Inonu University [IUBAP-09]en_US
dc.description.sponsorshipThe authors would like to thank Barbara Harris for carefully editing this manuscript. This study was supported by a grant from the Scientific Research Fund of Inonu University (IUBAP-09).en_US
dc.identifier.doi10.3906/kim-1706-8
dc.identifier.endpage49en_US
dc.identifier.issn1300-0527
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85065499681en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage39en_US
dc.identifier.trdizinid335491en_US
dc.identifier.urihttps://doi.org/10.3906/kim-1706-8
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/335491
dc.identifier.urihttps://hdl.handle.net/11616/92533
dc.identifier.volume43en_US
dc.identifier.wosWOS:000457575400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThiol antioxidanten_US
dc.subjectN-acetylcysteine amideen_US
dc.subjectparaquaten_US
dc.subjectneuroprotectiveen_US
dc.subjectglutathioneen_US
dc.titleThe protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicityen_US
dc.typeArticleen_US

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