In Vitro Caco-2 Cell Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanocrystals

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dc.authoridOzturk, Naile/0000-0002-7617-8433
dc.authoridKarakucuk, Alptug/0000-0002-9061-2427
dc.authoridCelebi, Nevin/0000-0002-6402-5042
dc.authorwosidKarakucuk, Alptug/JMQ-2136-2023
dc.authorwosidOzturk, Naile/F-3650-2017
dc.authorwosidKarakucuk, Alptug/AAI-2354-2019
dc.contributor.authorKarakucuk, Alptug
dc.contributor.authorTashan, Emine
dc.contributor.authorOzturk, Naile
dc.contributor.authorCelebi, Nevin
dc.date.accessioned2024-08-04T20:10:05Z
dc.date.available2024-08-04T20:10:05Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The current study focused on the evaluation of the cytotoxic effect and permeability of ziprasidone hydrochloride monohydrate (ZHM) nanocrystals on Caco-2 cells. Materials and Methods: ZHM nanocrystals were prepared by the microfluidization method in the presence of polyvinylpyrrolidone as a stabilizer. Particle size (PS), particle size distribution (PDI), and zeta potential (ZP) values were measured in characterization studies. In vitro cytotoxic effects of ZHM nanocrystals were investigated using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test. Caco-2 transport studies were conducted with formulations of ZHM coarse powder and nanocrystals. Results: Nanocrystals were obtained with 400-600 nm PS, 0.1-0.4 PDI, and >20 mV ZP values. The cell viability remained 100% for all sample groups. The permeability value of ZHM nanocrystals through Caco-2 cells increased 2.3-fold in comparison with ZHM coarse powder. Cumulative drug transport also increased at the end of the sampling period. Conclusion: Nanocrystal technology helps to increase the permeability of drug particles by increasing the saturation solubility.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [215S920]; (TUBITAK)en_US
dc.description.sponsorshipThis study was supported by a grant from The Scientific and Technological Research Council of Turkey (project no: 215S920, TUBITAK). The authors would like to thank Abdi Ibrahim for providing ZHM.en_US
dc.identifier.doi10.4274/tjps.galenos.2020.67366
dc.identifier.endpage227en_US
dc.identifier.issn1304-530X
dc.identifier.issue2en_US
dc.identifier.pmid33902264en_US
dc.identifier.scopus2-s2.0-85105234645en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage223en_US
dc.identifier.trdizinid480866en_US
dc.identifier.urihttps://doi.org/10.4274/tjps.galenos.2020.67366
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/480866
dc.identifier.urihttps://hdl.handle.net/11616/92591
dc.identifier.volume18en_US
dc.identifier.wosWOS:000647198000014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Pharmacists Assocen_US
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCaco-2 cellsen_US
dc.subjectpermeabilityen_US
dc.subjectziprasidoneen_US
dc.subjectnanocrystalen_US
dc.titleIn Vitro Caco-2 Cell Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanocrystalsen_US
dc.typeArticleen_US

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