Amelioration of subchronic acrylamide toxicity in large intestine of rats by organic dried apricot intake

Basit Öğe Kaydı
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorDogan, Zumrut
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorAkgoz, Muslum
dc.contributor.authorAltintoz, Eyup
dc.contributor.authorGecer, Murat
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2019-10-10T07:02:51Z
dc.date.available2019-10-10T07:02:51Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAcrylamide (AA) has neurotoxic, mutagenic, and genotoxic effects in humans and experimental animals. Fruit consumption is important for human health, because fruits are the source of many nutrients such as vitamins, minerals, carotenoids, dietary fiber, and phytonutrients. Many agricultural products provide natural melatonin in the diet. At the onset of the study, rats were weighted and randomly divided into four groups each containing 10 rats as follows: group 1: control (fed with normal diet and normal drinking water); group 2: apricot (fed with a daily diet with 5% apricot and normal drinking water); group 3: AA (administered daily acrylamide at 500 mu g/kg b.w. via drinking water and fed a normal diet); group 4: apricot-AA (administered daily acrylamide at 500 mu g/kg b.w. via drinking water and fed with a diet with 5% apricot). The diet schedule was continued for 12 weeks. At the end of the study, samples of large intestine were collected for biochemical analyses. The highest lipid peroxidation (as malondialdehyde, MDA) levels were observed in the AA groups, but MDA levels decreased significantly (P < 0.05) with apricot intake. Glutathione peroxidase activity in the apricot-AA group was higher than in the other three groups (P < 0.05). Glutathione S-transferase (GST) enzyme activity increased significantly in the AA group as compared with the other groups (P < 0.05). However, GST activity was significantly (P < 0.05) decreased by the apricot-supplemented diet. GST-Pi mRNA levels in the AA group increased significantly (P < 0.05) as compared with the other groups. In conclusion, the results of the current study demonstrated that AA caused large intestine damage and showed the efficiency of apricot in preventing this damage by inhibiting lipid peroxidation and improving antioxidant enzyme activities.en_US
dc.identifier.citationErdemli, ME. Dogan, Z . Cigremis, Y. Akgoz, M. Altintoz, E. Gecer, M. Turkoz, Y.(2015). Amelioration of subchronic acrylamide toxicity in large intestine of rats by organic dried apricot intake. Cilt:39. Sayı:6. 872- 878 ss.en_US
dc.identifier.doi10.3906/biy-1505-31en_US
dc.identifier.endpage878en_US
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84946717386en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage872en_US
dc.identifier.trdizinid351740en_US
dc.identifier.urihttps://doi.org/10.3906/biy-1505-31
dc.identifier.urihttps://hdl.handle.net/11616/14562
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/351740
dc.identifier.volume39en_US
dc.identifier.wosWOS:000365505600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubıtak scıentıfıc & technıcal research councıl turkey, ataturk bulvarı no 221, kavaklıdere, ankara, 00000, turkeyen_US
dc.relation.ispartofTurkısh journal of bıologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGene-expressıonen_US
dc.subjecttransferase-actıvıtyen_US
dc.subjectlıpıd-peroxıdatıonen_US
dc.subjectglutathıoneen_US
dc.subjectglycıdamıdeen_US
dc.subjectmetabolısmen_US
dc.subjectblooden_US
dc.titleAmelioration of subchronic acrylamide toxicity in large intestine of rats by organic dried apricot intakeen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
makale.pdf
Boyut:
203.81 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu