Efficacy of risperidone on positive and negative symptoms of schizophrenia and memory functions
Küçük Resim Yok
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: Symptoms due to cognitive impairment are common in patients with schizophrenia. Those are present before the onset of schizophrenia and are persistent during the course. It is important to relieve these symptoms as cognition is essential to maintain social functioning. Thus, the drugs which enhance cognitive, positive and negative symptoms of schizophrenia are desirable. In this context, the aim of this study has been to evaluate the efficacy of risperidone, a new atypical antipsychotic. Method: This study included twenty patients with schizophrenia. Diagnoses were made according to DSM-IV. Prior to institution, scores for BPRS, SANS, SAPS and Wechsler Memory Scale WMS-R were obtained. The patients received risperidone orally at a mean dosage of 5.60±1.23 mg daily. The scores obtained again at the end of week 6. Results: The differences between pretreatment and post treatment scores of BPRS, SAPS and SANS were statistically significant (p<0.001). All sub test scores in Wechsler Memory Scale (WMS-R) test were also statistically significant (p<0.001). Correlation analysis among variables showed negative correlation between BPRS, SAPS and logical memory and post treatment memory control and positive correlation between pretreatment mental control, figural memory and verbal paired associates and the same variables. Conclusions: The patients who were treated with risperidone in this study showed statistically significant improvement in positive and negative symptoms and cognitive functions. Improved cognitive functions were mental control, logical memory and visual reproductions. These results suggest an important role in both relieving positive and negative symptoms and improving cognitive functions for risperidone in patients with schizophrenia.
Açıklama
Anahtar Kelimeler
Cognitive functions, Negative symptoms, Positive symptoms, Risperidone
Kaynak
Klinik Psikofarmakoloji Bulteni
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
10
Sayı
4
