Efficacy of risperidone on positive and negative symptoms of schizophrenia and memory functions

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dc.authorscopusid7003374400
dc.authorscopusid55950466300
dc.authorscopusid7006083811
dc.authorscopusid7102067674
dc.contributor.authorÖzcan Y.
dc.contributor.authorÖzişik R.I.
dc.contributor.authorÜnal S.
dc.contributor.authorÖzcan M.E.
dc.date.accessioned2024-08-04T20:00:37Z
dc.date.available2024-08-04T20:00:37Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Symptoms due to cognitive impairment are common in patients with schizophrenia. Those are present before the onset of schizophrenia and are persistent during the course. It is important to relieve these symptoms as cognition is essential to maintain social functioning. Thus, the drugs which enhance cognitive, positive and negative symptoms of schizophrenia are desirable. In this context, the aim of this study has been to evaluate the efficacy of risperidone, a new atypical antipsychotic. Method: This study included twenty patients with schizophrenia. Diagnoses were made according to DSM-IV. Prior to institution, scores for BPRS, SANS, SAPS and Wechsler Memory Scale WMS-R were obtained. The patients received risperidone orally at a mean dosage of 5.60±1.23 mg daily. The scores obtained again at the end of week 6. Results: The differences between pretreatment and post treatment scores of BPRS, SAPS and SANS were statistically significant (p<0.001). All sub test scores in Wechsler Memory Scale (WMS-R) test were also statistically significant (p<0.001). Correlation analysis among variables showed negative correlation between BPRS, SAPS and logical memory and post treatment memory control and positive correlation between pretreatment mental control, figural memory and verbal paired associates and the same variables. Conclusions: The patients who were treated with risperidone in this study showed statistically significant improvement in positive and negative symptoms and cognitive functions. Improved cognitive functions were mental control, logical memory and visual reproductions. These results suggest an important role in both relieving positive and negative symptoms and improving cognitive functions for risperidone in patients with schizophrenia.en_US
dc.identifier.endpage188en_US
dc.identifier.issn1017-7833
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-52849136449en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage182en_US
dc.identifier.urihttps://hdl.handle.net/11616/90855
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofKlinik Psikofarmakoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCognitive functionsen_US
dc.subjectNegative symptomsen_US
dc.subjectPositive symptomsen_US
dc.subjectRisperidoneen_US
dc.titleEfficacy of risperidone on positive and negative symptoms of schizophrenia and memory functionsen_US
dc.title.alternativeRisperidonun şizofreninin pozitif ve negatif belirtileri ve bellek i?şlevi üzerine etkisien_US
dc.typeArticleen_US

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