Infection risk after paediatric liver transplantation

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridVarol, İlknur fatma/0000-0001-5212-218X
dc.authorwosidgungor, sukru/JNR-9592-2023
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidVarol, İlknur fatma/ABH-6387-2020
dc.contributor.authorSelimoglu, Mukadder Ayse
dc.contributor.authorKaya, Samime
dc.contributor.authorGungor, Sukru
dc.contributor.authorVarol, Fatma Ilknur
dc.contributor.authorBag, Harika Gozde Gozukara
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:10:00Z
dc.date.available2024-08-04T20:10:00Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractInfections after liver transplantation (LT), despite prophylactic therapy, are still important causes of morbidity and mortality in children. Although underlying disease and immunosuppression along with the complexity of LT procedure are the major predispositions to infections, there still might be under recognised factors predisposing infections in paediatric LT. In this study, we retrospectively analysed the risk factors of bacterial, viral, and fungal infections after LT in a series of 167 children (median =5 yr.). Of all children, 112 (67%) experienced infections: 93 (55.7%) bacterial, 56 (33.5%) viral and 15 (9%) fungal. Multilogistic regression analysis showed that the need of immunosuppressive switch increased total, bacterial, and viral infection risk 5.3, 2.5, and 2.5 times, respectively, (p=0.001, p=0.021, and p=0,019, respectively). Re-LT increased bacterial infection risk 4.2 times (p=0.040). Viral infection risk was 10 times higher in children who had more than two re-laparotomies (p=0,002). Children who had post-LT, cytomegalovirus (CMV) infection had 5.6 times increased risk for fungal infection (p=0.035). In conclusion, infection is still an important morbidity in paediatric LT and is in close relationship with other morbidities such as surgical complications. CMV infection, itself, is an independent risk factor for fungal infection.en_US
dc.identifier.doi10.24953/turkjped.2020.01.007
dc.identifier.endpage52en_US
dc.identifier.issn0041-4301
dc.identifier.issue1en_US
dc.identifier.pmid32253866en_US
dc.identifier.scopus2-s2.0-85083071411en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage46en_US
dc.identifier.trdizinid423270en_US
dc.identifier.urihttps://doi.org/10.24953/turkjped.2020.01.007
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/423270
dc.identifier.urihttps://hdl.handle.net/11616/92557
dc.identifier.volume62en_US
dc.identifier.wosWOS:000523556500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectchildrenen_US
dc.subjectinfectionen_US
dc.subjectliver transplantationen_US
dc.titleInfection risk after paediatric liver transplantationen_US
dc.typeArticleen_US

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