Synthesis of N-heterocyclic carbene-based silver complexes and their antimicrobial properties against bacteria and fungi
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
N-Heterocyclic carbene-based silver complexes (Ag-NHCs) have been widely used as organometallic drug candidates in medicinal and pharmaceutical chemistry research due to their low toxicity. Due to the success of Ag-NHCs in biological applications, interest in the synthesis and applications of such compounds is increasing rapidly. Therefore, in this study, ten Ag-NHC complexes containing benzimidazol-2-ylidene ligand were synthesized and characterized by H-1 NMR, C-13 NMR, FT-IR spectroscopies and elemental analyses. The antimicrobial activity of Ag-NHCs was tested against some standard culture collections of Gram-negative, Gram-positive bacterial strains and fungal strains, which are the most frequently isolated among the society and hospital acquired infectious microorganisms as potential metallopharmaceutical agents. The Ag-NHC complexes showed effective antimicrobial activity against microorganisms with MIC values between 6.25 and 100 mu g/mL.
Açıklama
Anahtar Kelimeler
N-Heterocyclic carbene, benzimidazol-2-ylidene, silver, antimicrobial activity, metallodrugs
Kaynak
Journal of Coordination Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
74
Sayı
17-20
