Tiroidin Warthin Benzeri Papiller Karsinomu
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Dosyalar
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi Tıp Fakültesi Dergisi
Erişim Hakkı
Attribution 3.0 United States
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Nadir bir tiroit karsinomu varyantı olan Warthin benzeri tiroit karsinomu olgumuz, 3 cm çapında kapsüllü, kısmen kistik nodüler yapıdadır. Mikroskopik olarak papiller yapıları döşeyen geniş alanlarda onkositik, yer yer papiller tiroit karsinomu hücrelerine ait morfolojik özellikte hücreler ve stromada yoğun lenfositik infiltrasyon mevcuttur. Tümör dışı alanlarda lenfositik tiroidit görünümü izlenmektedir. Son çalışmalarda bu lezyonların papiller karsinomun bir varyantı olarak kabul edilmesi gerektiği bildirilmektedir. Olgumuzu düşük ve yüksek ağırlıklı sitokeratin, epitelial membran antijen (EMA), HMB-45, S-100, T ve B lenfoid belirleyiciler ile inceleyerek tümör özelliklerini belirlemeyi amaçladık. Düşük ve yüksek ağırlıklı keratinler ve EMA ile boyanma saptadık. Hücre özellikleri papiller karsinom tall cell tipinden ayrımda önemlidir. Oksifilik tipte ise yoğun lenfositik infiltrasyon beklenen bir özellik değildir. Warthin benzeri papiller tiroit karsinomlarında literatürde bildirilen olgularda prognozun iyi olduğu belirtilmektedir. Bu nedenle kötü prognoza sahip bu iki tiroit karsinom tipinin Warthin benzeri tiroit karsinomundan ayrımı tanıda önemlidir.
We report a Warthin-like thyroid carcinoma as a rare variety of thyroid carcinoma. It is 3 cm in diameter, capsulated with a partly cystic-nodular pattern. There are oncocytic cells and cells morphologically belonging to papillary thyroid carcinoma in the large area covering a papillary pattern microscopically. There is dense lymphocyte rich stroma and a lymphocytic thyroiditis appearance outside the tumor nodule. In recent studies, it has been accepted as a variant of papillary carcinoma. In our case we attempted to determine the specifications of the tumour by using low and high molecular weight cytokeratin, epithelial membrane antigen, HMB -45, S-100, T and B lymphocyte markers. Tumor cells were positively stained with low and high weight cytokeratins and EMA. Differential diagnosis of the lesion from tall cell variant of thyroid carcinoma can be done by histopathological features. For the oxyphilic variant lymphoid infiltration is an uncommon feature. In literature, it was speculated that Warthin-like papillary thyroid carcinoma had a good prognosis. Therefore, So that, the differentiation of Warthin-like papillary carcinoma from those of the two variants, which have bad prognosis, has a great importance.
We report a Warthin-like thyroid carcinoma as a rare variety of thyroid carcinoma. It is 3 cm in diameter, capsulated with a partly cystic-nodular pattern. There are oncocytic cells and cells morphologically belonging to papillary thyroid carcinoma in the large area covering a papillary pattern microscopically. There is dense lymphocyte rich stroma and a lymphocytic thyroiditis appearance outside the tumor nodule. In recent studies, it has been accepted as a variant of papillary carcinoma. In our case we attempted to determine the specifications of the tumour by using low and high molecular weight cytokeratin, epithelial membrane antigen, HMB -45, S-100, T and B lymphocyte markers. Tumor cells were positively stained with low and high weight cytokeratins and EMA. Differential diagnosis of the lesion from tall cell variant of thyroid carcinoma can be done by histopathological features. For the oxyphilic variant lymphoid infiltration is an uncommon feature. In literature, it was speculated that Warthin-like papillary thyroid carcinoma had a good prognosis. Therefore, So that, the differentiation of Warthin-like papillary carcinoma from those of the two variants, which have bad prognosis, has a great importance.
Açıklama
Anahtar Kelimeler
Tiroit, Warthin Benzeri Karsinom, Thyroid, Warthin like, Carcinoma
Kaynak
İnönü Üniversitesi Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
8
Sayı
3
Künye
Kırımlıoğlu, Hale ;Zemheri, Ebru ; İnel, Fehmi ;(2001) İnönü Üniversitesi Tıp Fakültesi Dergisi.
