Immunhistochemical analysis of nuclear factor kappa beta expression in etiopathogenesis of ovariantumors
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ACTA CIRURGICA BRASILEIRA, ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To investigate the place of the transcription factor nuclear kappa B (NF-kappa B), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma.
Methods: NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kappa B expression in the ovarian tissue, the H-score method. H-score = Sigma Pi (i+1), where "Pi'' is the percentage of stained cells in each intensity category (0-100%) and "i'' is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3).
Results: It has been seen that, the mean H score is statistically significantly higher in the patient group with serous and musinous adenocarcinoma diagnosis than the two other patient groups (p<0.005).
Conclusions: Factor nuclear kappa B is an important mediator that acts in the chronic inflammation. The highest expression rates are determined by the immunohistochemical method in the ovarian cancer group.
Açıklama
Anahtar Kelimeler
Cell-Growth, Cancer, Polymorphısms, Progressıon
Kaynak
Acta cırurgıca brasıleıra
WoS Q Değeri
Scopus Q Değeri
Cilt
33
Sayı
7
Künye
Yılmaz, E. Gül, M. Melekoğlu, R. Köleli, I. (2018). Immunhistochemical analysis of nuclear factor kappa beta expression in etiopathogenesis of ovariantumors. Cilt:33 Sayı:7, 641-650 ss.
