Immunhistochemical analysis of nuclear factor kappa beta expression in etiopathogenesis of ovariantumors
| dc.contributor.author | Yılmaz, Ercan | |
| dc.contributor.author | Gül, Mehmet | |
| dc.contributor.author | Melekoğlu, Rauf | |
| dc.contributor.author | Köleli, Işıl | |
| dc.date.accessioned | 2019-07-17T06:54:40Z | |
| dc.date.available | 2019-07-17T06:54:40Z | |
| dc.date.issued | 2018 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Purpose: To investigate the place of the transcription factor nuclear kappa B (NF-kappa B), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma. Methods: NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kappa B expression in the ovarian tissue, the H-score method. H-score = Sigma Pi (i+1), where "Pi'' is the percentage of stained cells in each intensity category (0-100%) and "i'' is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3). Results: It has been seen that, the mean H score is statistically significantly higher in the patient group with serous and musinous adenocarcinoma diagnosis than the two other patient groups (p<0.005). Conclusions: Factor nuclear kappa B is an important mediator that acts in the chronic inflammation. The highest expression rates are determined by the immunohistochemical method in the ovarian cancer group. | en_US |
| dc.identifier.citation | Yılmaz, E. Gül, M. Melekoğlu, R. Köleli, I. (2018). Immunhistochemical analysis of nuclear factor kappa beta expression in etiopathogenesis of ovariantumors. Cilt:33 Sayı:7, 641-650 ss. | en_US |
| dc.identifier.doi | 10.1590/s0102-865020180070000009 | en_US |
| dc.identifier.endpage | 650 | en_US |
| dc.identifier.issue | 7 | en_US |
| dc.identifier.startpage | 641 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/12667 | |
| dc.identifier.volume | 33 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | ACTA CIRURGICA BRASILEIRA, ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL | en_US |
| dc.relation.ispartof | Acta cırurgıca brasıleıra | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Cell-Growth | en_US |
| dc.subject | Cancer | en_US |
| dc.subject | Polymorphısms | en_US |
| dc.subject | Progressıon | en_US |
| dc.title | Immunhistochemical analysis of nuclear factor kappa beta expression in etiopathogenesis of ovariantumors | en_US |
| dc.type | Article | en_US |
