Mean Platelet Volume Is a Poor Prognostic Factor in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma

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dc.contributor.authorSenturk, Mustafa
dc.contributor.authorInce, Volkan
dc.contributor.authorUreyen, Orhan
dc.contributor.authorEyvaz, Kemal
dc.contributor.authorIsik, Burak
dc.contributor.authorCarr, Brian, I
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2026-04-04T13:30:44Z
dc.date.available2026-04-04T13:30:44Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground/Aims: Mean platelet volume (MPV) reflects platelet activation. Platelets have an important role in tumor progression and metastasis. In this study, we wanted to investigate the effect of MPV on survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). Materials and Methods: All data of 376 patients who underwent LT and pathologically diagnosed with HCC were analyzed. Bydetermin- ing the cut-off of MPV (10.2 fL), 2 groups with high and low MPV were formed. The groups were compared within themselves. Factors affecting survival were determined by univariate and multivariate analysis. Results: When the groups were compared, patients with low MPV had significantly higher platelet counts, larger tumor sizes, lower BMI, and higher recurrence rates. In multivariate analysis, GGT >104, AFP >200 mu g/L, largest tumor diameter >5 cm, and lower MPV were found to be independent risk factors that affected the prognosis. Tumor-free survival was significantly worse in the lower MPV group (P = .002). Conclusion: Pre-transplant low MPV maybe useful in predicting poor prognosis and a high rate of tumor recurrence in patients with HCC after liver transplantation.
dc.identifier.doi10.5152/tjg.2025.24540
dc.identifier.issn2148-5607
dc.identifier.issue3
dc.identifier.orcid0000-0002-7820-9088
dc.identifier.orcid0000-0002-3230-1743
dc.identifier.orcid0000-0002-6111-5077
dc.identifier.orcid0000-0002-7410-107X
dc.identifier.orcid0000-0002-2395-3985
dc.identifier.orcid0000-0002-0714-490X
dc.identifier.pmid40091304
dc.identifier.scopus2-s2.0-105000354819
dc.identifier.scopusqualityQ3
dc.identifier.trdizinid1346277
dc.identifier.urihttps://doi.org/10.5152/tjg.2025.24540
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1346277
dc.identifier.urihttps://hdl.handle.net/11616/108351
dc.identifier.volume36
dc.identifier.wosWOS:001447453000006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectMPV
dc.subjecthepatocellular cancer
dc.subjecttransplantation
dc.titleMean Platelet Volume Is a Poor Prognostic Factor in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma
dc.typeArticle

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