Plasma D-lactic acid level: A useful marker to distinguish perforated from acute simple appendicitis
Küçük Resim Yok
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier (Singapore) Pte Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Early diagnosis of perforated appendicitis is important for reducing morbidity rates. The aim of this study was to determine the value and utility of plasma D-lactic acid levels in identifying the type of appendicitis. In this clinical study, plasma D-lactic acid levels were assessed in 44 consecutive paediatric patients (23 with acute appendicitis, 21 with perforated appendicitis) before laparotomy. D-lactic acid levels were determined by an enzymatic spectrophotometric technique using a D-lactic acid dehydrogenase kit. Patients with perforated appendicitis had higher D-lactic acid levels (3.970 ±0.687 mg/dL) than patients in the control group (0.478 ± 0.149 mg/dL) and patients with acute appendicitis (1.409 ±0.324 mg/dL; p < 0.05). For a plasma D-lactic acid level greater than 2.5 mg/dL, the sensitivity and specificity of the D-lactic acid assay were 96% and 87%, respectively. The positive predictive value was 87%, the negative predictive value was 96%, and the diagnostic value was 91%. These results suggest that the measurement of plasma D-lactic acid levels may be a useful adjunct to clinical and radiological findings in distinguishing perforated from acute non-perforated appendicitis in children.
Açıklama
Anahtar Kelimeler
dextro lactate dehydrogenase, dextro lactic acid, lactic acid, unclassified drug, acute appendicitis, adolescent, appendix perforation, article, child, clinical article, controlled study, diagnostic accuracy, diagnostic value, early diagnosis, human, lactate blood level, laparotomy, prediction, sensitivity and specificity, spectrophotometry
Kaynak
Asian Journal of Surgery
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
27
Sayı
4
