Plasma D-lactic acid level: A useful marker to distinguish perforated from acute simple appendicitis

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dc.authorscopusid57018844500
dc.authorscopusid57196653167
dc.authorscopusid6602665931
dc.authorscopusid6603951627
dc.authorscopusid36850343900
dc.authorscopusid6602415155
dc.contributor.authorDemircan M.
dc.contributor.authorCetin S.
dc.contributor.authorUguralp S.
dc.contributor.authorSezgin N.
dc.contributor.authorKaraman A.
dc.contributor.authorGozukara E.M.
dc.date.accessioned2024-08-04T19:59:40Z
dc.date.available2024-08-04T19:59:40Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEarly diagnosis of perforated appendicitis is important for reducing morbidity rates. The aim of this study was to determine the value and utility of plasma D-lactic acid levels in identifying the type of appendicitis. In this clinical study, plasma D-lactic acid levels were assessed in 44 consecutive paediatric patients (23 with acute appendicitis, 21 with perforated appendicitis) before laparotomy. D-lactic acid levels were determined by an enzymatic spectrophotometric technique using a D-lactic acid dehydrogenase kit. Patients with perforated appendicitis had higher D-lactic acid levels (3.970 ±0.687 mg/dL) than patients in the control group (0.478 ± 0.149 mg/dL) and patients with acute appendicitis (1.409 ±0.324 mg/dL; p < 0.05). For a plasma D-lactic acid level greater than 2.5 mg/dL, the sensitivity and specificity of the D-lactic acid assay were 96% and 87%, respectively. The positive predictive value was 87%, the negative predictive value was 96%, and the diagnostic value was 91%. These results suggest that the measurement of plasma D-lactic acid levels may be a useful adjunct to clinical and radiological findings in distinguishing perforated from acute non-perforated appendicitis in children.en_US
dc.identifier.doi10.1016/S1015-9584(09)60056-7
dc.identifier.endpage305en_US
dc.identifier.issn1015-9584
dc.identifier.issue4en_US
dc.identifier.pmid15564184en_US
dc.identifier.scopus2-s2.0-7044239112en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage303en_US
dc.identifier.urihttps://doi.org/10.1016/S1015-9584(09)60056-7
dc.identifier.urihttps://hdl.handle.net/11616/90814
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier (Singapore) Pte Ltden_US
dc.relation.ispartofAsian Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdextro lactate dehydrogenaseen_US
dc.subjectdextro lactic aciden_US
dc.subjectlactic aciden_US
dc.subjectunclassified drugen_US
dc.subjectacute appendicitisen_US
dc.subjectadolescenten_US
dc.subjectappendix perforationen_US
dc.subjectarticleen_US
dc.subjectchilden_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectdiagnostic accuracyen_US
dc.subjectdiagnostic valueen_US
dc.subjectearly diagnosisen_US
dc.subjecthumanen_US
dc.subjectlactate blood levelen_US
dc.subjectlaparotomyen_US
dc.subjectpredictionen_US
dc.subjectsensitivity and specificityen_US
dc.subjectspectrophotometryen_US
dc.titlePlasma D-lactic acid level: A useful marker to distinguish perforated from acute simple appendicitisen_US
dc.typeArticleen_US

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