SILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY

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dc.contributor.authorBaran, Ahmet Hüsamettin
dc.contributor.authorBerk, Ahmet
dc.contributor.authorUyumlu, Ayşe Burçin
dc.contributor.authorSolmaz, Özgen Arslan
dc.contributor.authorYalim, Göknur
dc.date.accessioned2026-04-04T13:19:05Z
dc.date.available2026-04-04T13:19:05Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective: This study aimed to evaluate the effects of sildenafil (SIL) on inflammation and histopathological changes in cadmium (Cd)-induced toxicity in female rats. Material and Method: Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF- α) levels were measured to assess the degree of inflammation. Histopathological changes in the liver, lungs and kidneys were also assessed. Result and Discussion: SIL significantly reduced the cellular release of TNF-α and IL-6, which have been implicated in the pathogenesis of Cd-induced tissue damage. When SIL was administered alone, it showed histopathological effects similar to the control group. However, it was found that co-administration of SIL with Cd prevented portal vein dilation and central vein enlargement in the liver, prevented necrosis in kidney tissue, but did not affect the lung. Although SIL has variable protective effects on tissues, our results are in support of the idea that the use of SIL in tissue damage management can be investigated for its efficacy in modulating oxidative stress-induced proinflammatory cytokine activation in vivo and ultimately help prevent Cd-induced tissue damage. Our study has shown that SIL can reduce Cd-induced acute toxicity in rats. SIL may be use as a protective agent against toxicity of heavy metals. © 2024 University of Ankara. All rights reserved.
dc.identifier.doi10.33483/jfpau.1443799
dc.identifier.endpage948
dc.identifier.issn2564-6524
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85207624910
dc.identifier.scopusqualityQ4
dc.identifier.startpage940
dc.identifier.trdizinid1262602
dc.identifier.urihttps://doi.org/10.33483/jfpau.1443799
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1262602
dc.identifier.urihttps://hdl.handle.net/11616/108129
dc.identifier.volume48
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherUniversity of Ankara
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250329
dc.subjectCadmium
dc.subjectliver enzymes
dc.subjectoxidative stress
dc.subjectsildenafil
dc.subjecttissue damage
dc.titleSILDENAFIL DECREASED TNF-α AND IL-6 LEVELS IN CD‐INDUCED ACUTE TOXICITY
dc.title.alternativeSİLDENAFİL CD İLE İNDÜKLENEN AKUT TOKSİSİTEDE TNF-α VE IL-6 DÜZEYLERİNİ DÜŞÜRÜR]
dc.typeArticle

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