Preparation of MWCNT-based poly (methacrylic acid) hybrid film modified sensors and their use in selective determination of levothyroxine
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Herein, the novel functional multi-walled carbon nanotube (MWCNT) hybrid material capable of rapid, ultra-sensitive, and accurate levothyroxine (L-T4) detection was synthesized for preparing modified sensors. Firstly, MWCNT was functionalized with triethoxyvinylsilane (TEVS). Vinyl functionalized MWCNT structures (MWCNT@TEVs) were treated with methacrylic acid (MA) and MA/divinylbenzene to synthesize two different hybrid polymers. These sensor materials were characterized in detail using Fourier transform infrared spectroscopy, energy dispersive X-ray analysis, scanning electron microscopy, and thermal analysis. The polymers were modified onto the glassy carbon electrode (GCE) surface by the drop-casting technique. The best-responsing sensor (MA-MWCNT@TEVS/GCE) was used for the rapid and sensitive detection of l-T4 in a wide concentration range using differential pulse voltammetry. The limit of detection for l-T4 was calculated as 0.26 nmol L--(1). The calibration curve R-2 value was determined as 0.9904 with a sensitivity of 0.408 A L nmol(-1) cm(-2) in the linear 4.0 - 44.0 mu mol L--(1) concentration range. Eventually, it was seen that poly (MA) based sensor materials could be an important alternative for the stable, sensitive, and reproducible determination of levothyroxine.
Açıklama
Anahtar Kelimeler
Voltammetric sensor, Modified sensor, Levothyroxine, MWCNT, Hybrit material
Kaynak
Electrochimica Acta
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
539
