Preparation of MWCNT-based poly (methacrylic acid) hybrid film modified sensors and their use in selective determination of levothyroxine

Basit Öğe Kaydı
dc.contributor.authorYayan, Emrah
dc.contributor.authorKazici, Dilek
dc.contributor.authorSavan, Ebru Kuyumcu
dc.contributor.authorOzcan, Imren
dc.contributor.authorKoytepe, Suleyman
dc.date.accessioned2026-04-04T13:35:08Z
dc.date.available2026-04-04T13:35:08Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractHerein, the novel functional multi-walled carbon nanotube (MWCNT) hybrid material capable of rapid, ultra-sensitive, and accurate levothyroxine (L-T4) detection was synthesized for preparing modified sensors. Firstly, MWCNT was functionalized with triethoxyvinylsilane (TEVS). Vinyl functionalized MWCNT structures (MWCNT@TEVs) were treated with methacrylic acid (MA) and MA/divinylbenzene to synthesize two different hybrid polymers. These sensor materials were characterized in detail using Fourier transform infrared spectroscopy, energy dispersive X-ray analysis, scanning electron microscopy, and thermal analysis. The polymers were modified onto the glassy carbon electrode (GCE) surface by the drop-casting technique. The best-responsing sensor (MA-MWCNT@TEVS/GCE) was used for the rapid and sensitive detection of l-T4 in a wide concentration range using differential pulse voltammetry. The limit of detection for l-T4 was calculated as 0.26 nmol L--(1). The calibration curve R-2 value was determined as 0.9904 with a sensitivity of 0.408 A L nmol(-1) cm(-2) in the linear 4.0 - 44.0 mu mol L--(1) concentration range. Eventually, it was seen that poly (MA) based sensor materials could be an important alternative for the stable, sensitive, and reproducible determination of levothyroxine.
dc.description.sponsorshipInonu University Research Fund Unit for priority area projects [FOA-2021-2690]
dc.description.sponsorshipThis study was supported by the Inonu University Research Fund Unit for priority area projects (Grant no. FOA-2021-2690) .
dc.identifier.doi10.1016/j.electacta.2025.147145
dc.identifier.issn0013-4686
dc.identifier.issn1873-3859
dc.identifier.orcid0000-0002-4788-278X
dc.identifier.orcid0000-0002-0437-5905
dc.identifier.orcid0000-0002-8851-0907
dc.identifier.scopus2-s2.0-105013539183
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.electacta.2025.147145
dc.identifier.urihttps://hdl.handle.net/11616/109642
dc.identifier.volume539
dc.identifier.wosWOS:001565764800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofElectrochimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectVoltammetric sensor
dc.subjectModified sensor
dc.subjectLevothyroxine
dc.subjectMWCNT
dc.subjectHybrit material
dc.titlePreparation of MWCNT-based poly (methacrylic acid) hybrid film modified sensors and their use in selective determination of levothyroxine
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu