Effect of Melatonin on Increasing the Effectiveness of Liver Preservation Solution

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dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.contributor.authorErdogan, Mehmet Mustafa
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorOzhan, Onural
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorBag, Harika Gozde Gozukara
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:10:22Z
dc.date.available2024-08-04T20:10:22Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Aims: Various tissue preservation solutions are used during the removal of the organ and during transplantation to protect the normal histological and biochemical characteristics of tissue while performing a successful liver transplant. In our study, it was aimed to investigate the effects of intraperitoneal melatonin administration on liver preservation damage before transplantation. Materials and Methods: In our study, the histological and biochemical characteristics of University of Wisconsin + melatonin group rats treated with melatonin 45 minutes before hepatectomy were compared between serum physiologic group and University of Wisconsin group. Results: When hematoxylin and eosin staining was evaluated in terms of hydropic degeneration, sinusoidal dilatation, and hepatocyte necrosis, there was no statistically significant difference. Caspase 3 immunohistochemical staining showed a significant increase in Caspase 3 immunoreactivity positivity at the 12th-hour University of Wisconsin group compared to University of Wisconsin + melatonin group. As a result of biochemical analysis, the malondialdehyde and total oxidant status levels in the University of Wisconsin + melatonin group decreased significantly compared to the University of Wisconsin group. When the reduced glutathione activity and total antioxidant capacity level were compared, a significant increase was observed in the University of Wisconsin + melatonin group compared to the University of Wisconsin group at the 12(th) hour. It was also found that aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase levels decreased significantly in the University of Wisconsin + melatonin 12(th)-hour group compared to the University of Wisconsin 12(th) hour and control group. Conclusion: When the findings were evaluated, intraperitoneal administration of melatonin, a cytoprotective antioxidant, was found to play an effective role in preserving immunohistochemical and biochemical properties of liver tissue integrity and hepatocytes in University of Wisconsin solution.en_US
dc.identifier.doi10.5152/tjg.2023.22694
dc.identifier.endpage951en_US
dc.identifier.issn2148-5607
dc.identifier.issue9en_US
dc.identifier.pmid37485562en_US
dc.identifier.scopus2-s2.0-85170111422en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage943en_US
dc.identifier.trdizinid1241537en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2023.22694
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1241537
dc.identifier.urihttps://hdl.handle.net/11616/92744
dc.identifier.volume34en_US
dc.identifier.wosWOS:001103159400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiveren_US
dc.subjectmelatoninen_US
dc.subjectpreservationen_US
dc.subjectUW solutionen_US
dc.titleEffect of Melatonin on Increasing the Effectiveness of Liver Preservation Solutionen_US
dc.typeArticleen_US

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