Risk of malignancy index is not sensitive in detecting non-epithelial ovarian cancer and borderline ovarian tumor
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Journal of the Turkish-German Gynecological Association
Erişim Hakkı
Attribution-NonCommercial-NoDerivs 3.0 United States
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Öz: Amaç: Adneksiyal kitlelerin değerlendirilmesinde ve over kanserini tanımada malignite risk endeksinin değerini araştırmak. Materyal ve Metod: Mayıs 2008 ve Ağustos 2009 tarihleri arasında adneksiyal kitle nedeniyle cerrahi uygulanması planlanan hastalar prospektif olarak çalışmaya dahil edildi. Malignite risk endeksi (MRE) daha önce yayınlanmış olan formül ile hesaplandı (MRE= ultrason puanı x menapozal durum x Ca-125 (IU/mL) seviyesi). MRE>200 olduğunda malignite pozitif olarak kabul edildi bu kestirim değerinin malign olguları saptamada ki duyarlılığı, özgüllüğü, pozitif öngörme değeri ve negatif öngörme değeri hesaplandı. Bulgular: Çalışmaya alınan 100 hastanın 80 tanesinde (%80) benign over kisti saptanırken, 4 tanesinde (%4) borderline over kanseri ve 16 tanesinde de (%16) invaziv over kanseri saptandı. Malign hastaların %45’i epitelyal over kanseri iken, %20’si (4/20) borderline, %30’u (6/20) epitelyal olmayan over kanseri ve %5’i de (1/20) appendiksten metastazdı. Tüm epitelyal over kanseri olgularının MRE pozitif iken borderline olguların dörtte birinin ve epitelyal olmayan over kanserli olguların altıda ikisinin MRE’si pozitifti. MRE’ nin tüm adneksiyal kitleler içinde over kanserini saptamadaki duyarlılığı %60, özgüllüğü %88.8, pozitif öngörme değeri %57.1 ve negatif öngörme değeri %89.9 idi. Epitelyal olmayan over kanserleri dışlandığında MRE’nin over kanserlerini tanımadaki duyarlılığı, özgüllüğü, negatif ve pozitif öngörme değerleri sırasıyla %76.9, %88.7, %52.6 ve %95.9 idi. Sonuç: Epitelyal olmayan kanser ve borderline over kanseri olgularının sıklığının yüksek olduğu bir toplulukta MRE, malign olguları tanımada yeterli değildir. (J Turkish-German Gynecol Assoc 2010; 11: 22-6)
Öz (İngilizce): Objective: To find out the value of risk of malignancy index in detection of ovarian cancer and referral of adnexal masses. Material and Method: Patients scheduled for surgery due to adnexal mass between the dates May 2008 and August 2009 were prospectively included to the study. Risk of malignancy index (RMI) was calculated for each patient with a published formula (RMI= Ultrasonic score X menopausal status X Ca-125 (IU/ml) level). RMI > 200 was accepted as positive for malignancy and the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of RMI in detecting malignant cases were calculated. Results: One hundred consecutive patients of whom 80 (80%) had benign ovarian cyst, 4 (4%) had borderline lesion and 16 (16%) had invasive ovarian cancer were included to the study. Forty-five percent (9/20) of malignant cases were epithelial ovarian cancer, 20% (4/20) were borderline ovarian tumor, 30% (6/20) were non-epithelial ovarian tumor and 5% (1/20) was a metastasis from appendix. All the cases with epithelial ovarian cancer had positive RMI but only 1 of 4 borderline lesions, 2 of 6 non-epithelial ovarian cancers had positive RMI. The sensitivity of RMI was 55%, specificity was 88.7%, PPV was 55% and NPV was 88.7% for all cases. When the cancer cases other than epithelial ovarian cancers were excluded the sensitivity, specificity, PPV and NPV of RMI was 76.92%, 88.75%, 52.63% and 95.95% respectively. Conclusions: RMI is not adequate in detecting malignant cases in a population with high non-epithelial ovarian cancer and borderline ovarian tumor prevalence.
Öz (İngilizce): Objective: To find out the value of risk of malignancy index in detection of ovarian cancer and referral of adnexal masses. Material and Method: Patients scheduled for surgery due to adnexal mass between the dates May 2008 and August 2009 were prospectively included to the study. Risk of malignancy index (RMI) was calculated for each patient with a published formula (RMI= Ultrasonic score X menopausal status X Ca-125 (IU/ml) level). RMI > 200 was accepted as positive for malignancy and the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of RMI in detecting malignant cases were calculated. Results: One hundred consecutive patients of whom 80 (80%) had benign ovarian cyst, 4 (4%) had borderline lesion and 16 (16%) had invasive ovarian cancer were included to the study. Forty-five percent (9/20) of malignant cases were epithelial ovarian cancer, 20% (4/20) were borderline ovarian tumor, 30% (6/20) were non-epithelial ovarian tumor and 5% (1/20) was a metastasis from appendix. All the cases with epithelial ovarian cancer had positive RMI but only 1 of 4 borderline lesions, 2 of 6 non-epithelial ovarian cancers had positive RMI. The sensitivity of RMI was 55%, specificity was 88.7%, PPV was 55% and NPV was 88.7% for all cases. When the cancer cases other than epithelial ovarian cancers were excluded the sensitivity, specificity, PPV and NPV of RMI was 76.92%, 88.75%, 52.63% and 95.95% respectively. Conclusions: RMI is not adequate in detecting malignant cases in a population with high non-epithelial ovarian cancer and borderline ovarian tumor prevalence.
Açıklama
Yıl: 2010Cilt: 11Sayı: 1ISSN: 1309-0399Sayfa Aralığı: 22 - 26
Anahtar Kelimeler
Kadın Hastalıkları ve Doğum
Kaynak
Journal of the Turkish-German Gynecological Association
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
11
Sayı
1
Künye
MEYDANLI, M.M., (2010). Risk of malignancy index is not sensitive in detecting non-epithelial ovarian cancer and borderline ovarian tumor. Journal of the Turkish-German Gynecological Association, 11(1), 22-26.
