The beneficial effect of melatonin on chronic cyclosporin A nephrotoxicity in rats
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cambridge Med Publ
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Cyclosporin A (CsA)-induced nephrotoxicity may be the consequence of oxidative stress. Anti-oxidant agents could be useful in reducing CsA toxicity. In this light microscopy study, tubular dilatation, atrophy, vacuolization and tubulointerstitial fibrosis were observed in rats given CsA, whereas in rats given CsA plus melatonin, no histological changes occurred. It is concluded that melatonin could be useful for reducing the nephrotoxic effects of CsA.
Açıklama
Anahtar Kelimeler
cyclosporin A, melatonin, anti-oxidant, nephrotoxicity, rat, light microscopy, tubulointerstitial fibrosis, tubular atrophy
Kaynak
Journal of International Medical Research
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
31
Sayı
1
