Distribution of peripheral blood cells after splenectomy in immune thrombocytopenia patients

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dc.contributor.authorSimsek, Arife
dc.date.accessioned2024-08-04T20:51:48Z
dc.date.available2024-08-04T20:51:48Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: There are some difficulties regarding the evaluation of the post-splenectomy state. Objective: The objective of the study is to compare the post-splenectomy blood changes of immune thrombocytopenia (ITP) patients with those of trauma patients, 1 month and >_ 6 months after surgery. Methods: Medical records of patients, who had undergone total splenectomy for ITP and trauma at a tertiary center between January 2009 and December 2019, were retrospectively reviewed. Results: The current study included 52 patients, who had undergone splenectomy for ITP (57.7%), and trauma (42.3%). Splenectomy, irrespective of the indications, resulted in an increase in hemoglobin concentration, hematocrit, and platelet levels. Neutrophils were responsible for the preoperative leukocytosis in ITP patients, and neutrophilia was ameliorated by splenectomy and also withdrawal of the steroid therapy in some patients. Decreased neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio supported the finding that splenectomy ameliorated inflammation in ITP patients. Splenectomy resulted in a change in percentages of leukocytes in favor of basophils in ITP patients. Conclusions: Splenectomy, irrespective of the indications, resulted in an increase in hemoglobin concentration, hematocrit and platelet levels, lymphocyte, monocyte, and eosinophil counts. Splenectomy ameliorated inflammation in ITP patients and resulted in a change in percentages of leukocytes in favor of basophils.en_US
dc.identifier.doi10.24875/CIRU.21000246
dc.identifier.endpage164en_US
dc.identifier.issn0009-7411
dc.identifier.issue2en_US
dc.identifier.pmid35349562en_US
dc.identifier.scopus2-s2.0-85127235259en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://doi.org/10.24875/CIRU.21000246
dc.identifier.urihttps://hdl.handle.net/11616/100569
dc.identifier.volume90en_US
dc.identifier.wosWOS:000787372000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMexican Acad Surgeryen_US
dc.relation.ispartofCirugia Y Cirujanosen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectImmune thrombocytopeniaen_US
dc.subjectNeutrophil-to-lymphocyte ratioen_US
dc.subjectPeripheral blood cellsen_US
dc.subjectSplenectomyen_US
dc.subjectTraumaen_US
dc.titleDistribution of peripheral blood cells after splenectomy in immune thrombocytopenia patientsen_US
dc.typeArticleen_US

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