Evaluation of serum neopterin, periostin, Tenascin-C, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant women

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dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridyuce, hande/0000-0003-2907-2019
dc.authoridunuvar, songul/0000-0001-8454-490X
dc.authoridCETIN, Asli/0000-0003-3902-3210
dc.authoridYASAR, Seyma/0000-0003-1300-3393
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidYaşar, Şeyma/ABI-8055-2020
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorUnuvar, Songul
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorCetin, Asli
dc.contributor.authorCelik, Nesibe Zeyveli
dc.contributor.authorYuce, Hande
dc.contributor.authorYasar, Seyma
dc.date.accessioned2024-08-04T20:10:19Z
dc.date.available2024-08-04T20:10:19Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To investigate the role of extracellular matrix proteins in the molecular mechanism of inflammatory response in obese pregnant women by comparing serum levels of neopterin, periostin, Tenascin-C, tissue inhibitor of metalloproteinase-1, and matrix metalloproteinase-2 between obese and normal weight pregnant women in the third trimester. Materials and Methods: A prospective cross-sectional study was conducted between April 2021 and December 2021. A total of 84 pregnant women were included and three groups were formed with 28 participants in each group. Results: Serum levels of neopterin, periostin, Tenascin-C and tissue inhibitor of metalloproteinase-1 were significantly higher in class II-III obese pregnant women than in class I obese and normal-weight women (p=0.002, p<0.001, p<0.001, and p<0.001, respectively). There was no significant difference in serum matrix metalloproteinase-2 levels between the groups (p=0.769). Receiver operating characteristic curve analysis showed that Tenascin-C and periostin were effective in predicting pre-eclampsia [area under the curve (AUC)=0.82, 95% confidence interval (CI), 0.72-0.90, p<0.001 and AUC=0.71, 95% CI, 0.60-0.80, p=0.007, respectively]. Conclusion: This study demonstrated that class II-III obese pregnant women had significantly higher serum levels of neopterin, periostin, Tenascin-C, and tissue inhibitor of metalloproteinase-1 in the third trimester. These higher serum levels may be associated with the adverse perinatal effects of obesity during pregnancy.en_US
dc.identifier.doi10.4274/tjod.galenos.2022.70593
dc.identifier.endpage267en_US
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue4en_US
dc.identifier.pmid36511564en_US
dc.identifier.scopus2-s2.0-85147038554en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage257en_US
dc.identifier.trdizinid1175376en_US
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2022.70593
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1175376
dc.identifier.urihttps://hdl.handle.net/11616/92696
dc.identifier.volume19en_US
dc.identifier.wosWOS:000921197500003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeopterinen_US
dc.subjectobesityen_US
dc.subjectperiostinen_US
dc.subjectpregnancyen_US
dc.subjectTenascin-Cen_US
dc.subjecttissue inhibitor of metalloproteinase-1en_US
dc.titleEvaluation of serum neopterin, periostin, Tenascin-C, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant womenen_US
dc.typeArticleen_US

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