Daily consensus interferon (CIFN) monotherapy in non-responders or relapsers to a previous interferon regime: One year follow-up after 48 weeks of treatment

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dc.authorscopusid6701920045
dc.authorscopusid7004623776
dc.authorscopusid7202463116
dc.authorscopusid7004015279
dc.contributor.authorAlada? M.
dc.contributor.authorKarasu Z.
dc.contributor.authorWright H.
dc.contributor.authorGürakar A.
dc.date.accessioned2024-08-04T20:01:01Z
dc.date.available2024-08-04T20:01:01Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aims: Data suggests on the basis of thrice a week therapy, efficacy of mono consensus interferon is comparable to other alpha interferons. One-year follow-up after 12-month daily consensus interferon monotherapy for chronic hepatitis C among non-responders or relapsers to previous consensus interferon monotherapy is investigated. Methods: Between February and August 1998, 11 non-cirrhotic patients with previous consensus interferon failure were treated. Six were relapsers and five non-responders. Serum HCV-RNA was tested at the 12th and 48th weeks of treatment and followed for one year thereafter. Results: Eight (72%) were HCV-RNA negative at both 12th and 48th weeks. Of these, 60% (3/5) were among previous non-responders and 83% (5/6) were among previous relapsers. One year sustained virological response was 55%. Of this, 40% (2/5) were among non-responders and 66% (4/6) previous relapsers. Conclusions: These findings suggest that daily consensus interferon needs to be further investigated as an alternative to pegylated formulations, especially with the addition of ribavirin.en_US
dc.identifier.endpage39en_US
dc.identifier.issn1300-4948
dc.identifier.issue1en_US
dc.identifier.pmid16830275en_US
dc.identifier.scopus2-s2.0-34047238994en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage35en_US
dc.identifier.trdizinid63815en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/63815
dc.identifier.urihttps://hdl.handle.net/11616/91206
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic hepatitis Cen_US
dc.subjectDaily consensus interferonen_US
dc.subjectSustained virologic responseen_US
dc.titleDaily consensus interferon (CIFN) monotherapy in non-responders or relapsers to a previous interferon regime: One year follow-up after 48 weeks of treatmenten_US
dc.typeArticleen_US

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