AGE-RELATED-CHANGES IN CATALASE, GLUTATHIONE-REDUCTASE ACTIVITIES, THE AMOUNT OF GLUTATHIONE IN TOTAL-BODY OF OREGON AND VESTIGIAL DROSOPHILA-MELANOGASTER
Küçük Resim Yok
Tarih
1994
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Natural antioxidants, free radical scavengers as catalase, glutathione reductase and glutathione are considered for aging mechanism. The objective of our study was to investigate the differences in the life span of male Oregon (w.t.) and vestigial Drosophila melanogaster, the possible role of free radical scavengers such as catalase, glutathione reductase and reduced-oxidized glutathione levels in the aging process by studying the pattern of age-related changes. The life span of male Oregon D. melanogaster is longer than that of the vestigial D. melanogaster. The beginning of the dying phase of Oregon was around 40 days, while the vestigial's around 20 days. The maximum life span was 85 days in Oregon population and 56 days in vestigial population. Age-related changes of catalase activities were similar in male Oregon and vestigial and showed a decreasing curve during aging. Glutathione reductase activity of Oregon increased slightly between 10 and 40 days, decreased sharply thereafter. Glutathione reductase activity of vestigial followed a pot-shaped trend with 60 % decrease during the first 40 days and followed by a sharp increase during the late part of life. The amounts of reduced glutathione (GSH) and oxidized glutathione (GSSG) increased slightly up to 40 days of age and followed a sharp decline thereafter in male Oregon D. melanogaster. In male vestigial D. melanogaster, the concentrations of GSH and GSSG remained quite stable for the first 10 days, followed by a sharp decline around 20th day and increased thereafter.
Açıklama
Anahtar Kelimeler
ANTIOXIDANTS, FREE RADICAL SCAVENGERS, CATALASE, GLUTATHIONE REDUCTASE, GLUTATHIONE, DROSOPHILA MELANOGASTER
Kaynak
Archives of Gerontology and Geriatrics
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
