AGE-RELATED-CHANGES IN CATALASE, GLUTATHIONE-REDUCTASE ACTIVITIES, THE AMOUNT OF GLUTATHIONE IN TOTAL-BODY OF OREGON AND VESTIGIAL DROSOPHILA-MELANOGASTER

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dc.authoridYesilada, Elif/0000-0002-3743-5767
dc.authoridAsma, Dilek/0000-0002-3866-3016
dc.authorwosidYesilada, Elif/ABG-9600-2020
dc.authorwosidFiskin, Kayahan/C-2434-2016
dc.authorwosidAsma, Dilek/AAA-5294-2021
dc.contributor.authorFISKIN, K
dc.contributor.authorKANDEMIR, S
dc.contributor.authorHAMAMCI, D
dc.contributor.authorYESILADA, E
dc.contributor.authorBOZCUK, AN
dc.date.accessioned2024-08-04T20:11:49Z
dc.date.available2024-08-04T20:11:49Z
dc.date.issued1994
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNatural antioxidants, free radical scavengers as catalase, glutathione reductase and glutathione are considered for aging mechanism. The objective of our study was to investigate the differences in the life span of male Oregon (w.t.) and vestigial Drosophila melanogaster, the possible role of free radical scavengers such as catalase, glutathione reductase and reduced-oxidized glutathione levels in the aging process by studying the pattern of age-related changes. The life span of male Oregon D. melanogaster is longer than that of the vestigial D. melanogaster. The beginning of the dying phase of Oregon was around 40 days, while the vestigial's around 20 days. The maximum life span was 85 days in Oregon population and 56 days in vestigial population. Age-related changes of catalase activities were similar in male Oregon and vestigial and showed a decreasing curve during aging. Glutathione reductase activity of Oregon increased slightly between 10 and 40 days, decreased sharply thereafter. Glutathione reductase activity of vestigial followed a pot-shaped trend with 60 % decrease during the first 40 days and followed by a sharp increase during the late part of life. The amounts of reduced glutathione (GSH) and oxidized glutathione (GSSG) increased slightly up to 40 days of age and followed a sharp decline thereafter in male Oregon D. melanogaster. In male vestigial D. melanogaster, the concentrations of GSH and GSSG remained quite stable for the first 10 days, followed by a sharp decline around 20th day and increased thereafter.en_US
dc.identifier.doi10.1016/S0167-4943(05)80052-4
dc.identifier.endpage90en_US
dc.identifier.issn0167-4943
dc.identifier.issn1872-6976
dc.identifier.pmid18649847en_US
dc.identifier.scopus2-s2.0-0028219310en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.1016/S0167-4943(05)80052-4
dc.identifier.urihttps://hdl.handle.net/11616/93003
dc.identifier.wosWOS:A1994NK65200012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofArchives of Gerontology and Geriatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectANTIOXIDANTSen_US
dc.subjectFREE RADICAL SCAVENGERSen_US
dc.subjectCATALASEen_US
dc.subjectGLUTATHIONE REDUCTASEen_US
dc.subjectGLUTATHIONEen_US
dc.subjectDROSOPHILA MELANOGASTERen_US
dc.titleAGE-RELATED-CHANGES IN CATALASE, GLUTATHIONE-REDUCTASE ACTIVITIES, THE AMOUNT OF GLUTATHIONE IN TOTAL-BODY OF OREGON AND VESTIGIAL DROSOPHILA-MELANOGASTERen_US
dc.typeArticleen_US

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