Production of methionine ?- lyase in recombinant Citrobacter freundii bearing the hemoglobin gene

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dc.authoridKahraman, Hüseyin/0000-0001-6235-5497;
dc.authorwosidKahraman, Hüseyin/ABG-9650-2020
dc.authorwosidGiray Kurt, Aslı/J-8877-2014
dc.contributor.authorKahraman, Huseyin
dc.contributor.authorAytan, Emel
dc.contributor.authorKurt, Ash Giray
dc.date.accessioned2024-08-04T20:35:41Z
dc.date.available2024-08-04T20:35:41Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe production of antileukemic enzyme methionine gamma-lyase (MGL) in distinctly related bacteria, Citrobacter freundii and in their recombinants expressing the Vitresocilla hemoglobin (VHb) has been studied. This study concerns the potential of Citrobacter freundii expressing the Vitreoscilla hemoglobin gene (vgb) for the methionine gamma- liyase production. Methionine gamma- liyase production by Citrobacter freundii and its vgb(-) and vgb(+) bearing recombinant strain was studied in shake-flasks under 200 rpm agitation, culture medium and 30 degrees C in a time-course manner. The vgb(+) and especially the carbon type had a dramatic effect on methionine gamma- liyase production. The vgb(+) strain of C. freundii had about 2-fold and 3.1-fold higher levels of MGL than the host and vgb(-) strain, respectively. [BMB reports 2011; 44(9): 590-594]en_US
dc.identifier.doi10.5483/BMBRep.2011.44.9.590
dc.identifier.endpage594en_US
dc.identifier.issn1976-6696
dc.identifier.issue9en_US
dc.identifier.pmid21944252en_US
dc.identifier.scopus2-s2.0-83655192734en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage590en_US
dc.identifier.urihttps://doi.org/10.5483/BMBRep.2011.44.9.590
dc.identifier.urihttps://hdl.handle.net/11616/95511
dc.identifier.volume44en_US
dc.identifier.wosWOS:000295485800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Society Biochemistry & Molecular Biologyen_US
dc.relation.ispartofBmb Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntitumour efficacyen_US
dc.subjectCitrobacter freundiien_US
dc.subjectMethionine gamma-lyaseen_US
dc.subjectVitreoscilla hemoglobinen_US
dc.titleProduction of methionine ?- lyase in recombinant Citrobacter freundii bearing the hemoglobin geneen_US
dc.typeArticleen_US

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