Synthesis and Antimalarial Bioassay of Quinine - Peptide Conjugates
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100nm, similar to quinine.
Açıklama
Anahtar Kelimeler
amino acid, chemical biology, drug design, peptide
Kaynak
Chemical Biology & Drug Design
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
82
Sayı
4
