Evaluation of the therapeutic effects of the topical and systemic forms of Honokiol in 5-fluorouracil-induced oral mucositis model in rats
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nature Portfolio
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study aimed to evaluate the effects of honokiol on 5-florourasil (5-FU) induced oral mucositis (OM) in rats. A total of 24 female Wistar Albino rats were injected with 5-FU on day 1, 3 and 5. A superficial scratch was linearly created on the right buccal mucosa on days 3 and 5. The animals were randomly divided into control, vehicle, topical honokiol and systemic honokiol groups and sacrificed on the day 10 after the first 5-FU application. Blood and tissue sampling were analysed for total antioxidant status (TAS) levels, total oxidant status (TOS) levels plus histopathological evaluations. When the systemic and topical groups and vehicle group compared to control group, no statistically significant difference was found histopathological scores. (p = 1.000, p = 0.264, p = 1.000, respectively). There were no significance differences in histopathological scores between systemic and topical groups (p = 1.000), or between systemic and vehicle groups (p = 0.139). A statistically significant difference was observed in the histopathologic analysis between the topical and vehicle groups, (p = 0.006). There were no differences in TAS and TOS between the groups. The authors found no beneficial effect of systemic or topical honokiol on healing 5-FU-induced OM. To confirm its effects on OM, further studies are required with different study designs.
Açıklama
Anahtar Kelimeler
Oral mucositis, 5-florourasil, Honokiol, Healing, Oxidative stress, Histopathology score
Kaynak
Scientific Reports
WoS Q Değeri
Q1
Scopus Q Değeri
N/A
Cilt
15
Sayı
1
