Evaluation of the therapeutic effects of the topical and systemic forms of Honokiol in 5-fluorouracil-induced oral mucositis model in rats

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dc.contributor.authorKucuk, Ayse Ozcan
dc.contributor.authorKeskinruzgar, Aydin
dc.contributor.authorBozdag, Zehra
dc.date.accessioned2026-04-04T13:34:41Z
dc.date.available2026-04-04T13:34:41Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractThis study aimed to evaluate the effects of honokiol on 5-florourasil (5-FU) induced oral mucositis (OM) in rats. A total of 24 female Wistar Albino rats were injected with 5-FU on day 1, 3 and 5. A superficial scratch was linearly created on the right buccal mucosa on days 3 and 5. The animals were randomly divided into control, vehicle, topical honokiol and systemic honokiol groups and sacrificed on the day 10 after the first 5-FU application. Blood and tissue sampling were analysed for total antioxidant status (TAS) levels, total oxidant status (TOS) levels plus histopathological evaluations. When the systemic and topical groups and vehicle group compared to control group, no statistically significant difference was found histopathological scores. (p = 1.000, p = 0.264, p = 1.000, respectively). There were no significance differences in histopathological scores between systemic and topical groups (p = 1.000), or between systemic and vehicle groups (p = 0.139). A statistically significant difference was observed in the histopathologic analysis between the topical and vehicle groups, (p = 0.006). There were no differences in TAS and TOS between the groups. The authors found no beneficial effect of systemic or topical honokiol on healing 5-FU-induced OM. To confirm its effects on OM, further studies are required with different study designs.
dc.description.sponsorshipUnit of Scientific Research Projects Fund of Mersin University [2019-1-AP7-3192]; Unit of Scientific Research Projects Fund of Mersin University, Mersin, Turkey
dc.description.sponsorshipThis study was supported by the Unit of Scientific Research Projects Fund of Mersin University, Mersin, Turkey (Process number: 2019-1-AP7-3192). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.identifier.doi10.1038/s41598-025-04628-7
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid40461551
dc.identifier.scopus2-s2.0-105007137468
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1038/s41598-025-04628-7
dc.identifier.urihttps://hdl.handle.net/11616/109342
dc.identifier.volume15
dc.identifier.wosWOS:001502174400003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectOral mucositis
dc.subject5-florourasil
dc.subjectHonokiol
dc.subjectHealing
dc.subjectOxidative stress
dc.subjectHistopathology score
dc.titleEvaluation of the therapeutic effects of the topical and systemic forms of Honokiol in 5-fluorouracil-induced oral mucositis model in rats
dc.typeArticle

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