Relationship between activation and apoptosis in platelets

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dc.authorscopusid6603697741
dc.authorscopusid6603405386
dc.authorscopusid23391765700
dc.contributor.authorÖzgen Ü.
dc.contributor.authorÖzerol E.
dc.contributor.authorAminci M.
dc.date.accessioned2024-08-04T20:01:09Z
dc.date.available2024-08-04T20:01:09Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPhosphatidylserine (PS) externalization is a marker for the nucleated cell apoptosis, and refers cellular activation rather than apoptosis in platelets. On the other hand, several similarities exist between platelet activation and apoptosis in nucleated cells. Herewith we investigated the relationship between platelet activation and platelet apoptosis. Platelets isolated from fresh blood of 22 healthy volunteers were incubated with and without calcium ionophore A23187. Platelet activation was evaluated with CD62P and CD63 antibodies, whereas apoptosis with intracellular anti caspase 3-antibody and JC-1 cationic dye. In order to detect PS externalization we used Annexin V by flow cytometry at the beginning, 20th minute and 5th hours of the incubation, respectively. There were positive correlations between caspase-3 activation and PS externaization, ??m depolarization, CD63, and also between PS externaization and CD62P in incubations with A23187 at 5th hours of incubations. These results suggest that there is a relationship between activation and apoptosis in platelets, and platelet activation may progress to platelet apoptosis. © Turkish Society of Hematology.en_US
dc.identifier.endpage177en_US
dc.identifier.issn1300-7777
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-38049119759en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage171en_US
dc.identifier.trdizinid75530en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/75530
dc.identifier.urihttps://hdl.handle.net/11616/91295
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnnexin Ven_US
dc.subjectApoptosisen_US
dc.subjectPhosphatdylserineen_US
dc.subjectPlatelet activationen_US
dc.titleRelationship between activation and apoptosis in plateletsen_US
dc.typeArticleen_US

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