Dynamic magnetic resonance imaging in determining histopathological prognostic factors of invasive breast cancers
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To evaluate the relation between morphological features and enhancement parameters in dynamic contrast-enhanced magnetic resonance (DCE-MR) imaging with histopathological prognostic factors. Materials and methods: Fifty-five patients with surgicopathological diagnosis of breast carcinoma were evaluated with 1.0 T MR scanner as a part of their preoperative diagnostic work-up. Dynamic studies were performed in axial plane using 3D fast low angle shot (FLASH) sequence. Time intensity curves (TICs) were obtained from the regions showing maximal enhancement in subtraction images. The correlations between enhancement parameters and histopathological findings were analyzed using stepwise multiple regression analysis, Student's t-test, chi(2)-tests and Pearson's moment correlation coefficient. Results: Significant correlations were found between the presence of lymph node metastasis and tumor size (P < 0.05) and edge characteristics (P < 0.05). A highly significant correlation was found between histopathological grades and qualitative enhancement patterns (r = 0.403, P < 0.01). Statistically significant differences were found between the groups with and without lymph node metastasis regarding enhancement in the first minute (P < 0.01) and TIC slope (P < 0.05). A significant difference was found between the histopathological grades I and III regarding all quantitative enhancement parameters, whereas no difference was found between the grades I-II, and II-III. Conclusion: DCE-MR imaging helps to predict prognostic factors of breast cancer by revealing morphological features and enhancement parameters of the primary tumor. Additional morphological factors further improve our ability to predict lymphatic metastasis. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
dynamic MRI, invasive breast cancer, contrast enhancement, prognostic factors
Kaynak
European Journal of Radiology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
53
Sayı
2
