Dynamic magnetic resonance imaging in determining histopathological prognostic factors of invasive breast cancers

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dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.contributor.authorTuncbilek, N
dc.contributor.authorKarakas, HM
dc.contributor.authorOkten, OO
dc.date.accessioned2024-08-04T20:13:42Z
dc.date.available2024-08-04T20:13:42Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To evaluate the relation between morphological features and enhancement parameters in dynamic contrast-enhanced magnetic resonance (DCE-MR) imaging with histopathological prognostic factors. Materials and methods: Fifty-five patients with surgicopathological diagnosis of breast carcinoma were evaluated with 1.0 T MR scanner as a part of their preoperative diagnostic work-up. Dynamic studies were performed in axial plane using 3D fast low angle shot (FLASH) sequence. Time intensity curves (TICs) were obtained from the regions showing maximal enhancement in subtraction images. The correlations between enhancement parameters and histopathological findings were analyzed using stepwise multiple regression analysis, Student's t-test, chi(2)-tests and Pearson's moment correlation coefficient. Results: Significant correlations were found between the presence of lymph node metastasis and tumor size (P < 0.05) and edge characteristics (P < 0.05). A highly significant correlation was found between histopathological grades and qualitative enhancement patterns (r = 0.403, P < 0.01). Statistically significant differences were found between the groups with and without lymph node metastasis regarding enhancement in the first minute (P < 0.01) and TIC slope (P < 0.05). A significant difference was found between the histopathological grades I and III regarding all quantitative enhancement parameters, whereas no difference was found between the grades I-II, and II-III. Conclusion: DCE-MR imaging helps to predict prognostic factors of breast cancer by revealing morphological features and enhancement parameters of the primary tumor. Additional morphological factors further improve our ability to predict lymphatic metastasis. (C) 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejrad.2003.11.004
dc.identifier.endpage205en_US
dc.identifier.issn0720-048X
dc.identifier.issn1872-7727
dc.identifier.issue2en_US
dc.identifier.pmid15664283en_US
dc.identifier.scopus2-s2.0-12444264929en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage199en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejrad.2003.11.004
dc.identifier.urihttps://hdl.handle.net/11616/93795
dc.identifier.volume53en_US
dc.identifier.wosWOS:000227004600007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEuropean Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdynamic MRIen_US
dc.subjectinvasive breast canceren_US
dc.subjectcontrast enhancementen_US
dc.subjectprognostic factorsen_US
dc.titleDynamic magnetic resonance imaging in determining histopathological prognostic factors of invasive breast cancersen_US
dc.typeArticleen_US

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