Beneficial effects of glucan against cisplatin side effects on the nervous system in rats 1
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Acta cir brasl
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
PURPOSE: To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats.
METHODS: Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group,
CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, βg was orally administered at the dose of 50 mg/kg/day
for 14 days. In the fourth group, CP and βg were given together at the same doses.
RESULTS: CP treatment caused significant oxidative damage via induction of lipid peroxidation and reductions antioxidant defense
system potency in the brain tissue. In addition, histopathological damage increased with CP treatment. On the other hand, βg treatment
largely prevented oxidative and histopathological negative effects of CP.
CONCLUSIONS: Cisplatin has severe neurotoxic effects in rats and βg supplementation has significant beneficial effects against CP
toxicity depending on its antioxidant properties. Thus, it appears that βg might be useful against CP toxicity in patients with cancer in
terms of nervous system.
Açıklama
Anahtar Kelimeler
Cisplatin, Beta-Glucans, Nervous System, Oxidative Stress, Rast
Kaynak
Acta cir brasl
WoS Q Değeri
Scopus Q Değeri
Cilt
31
Sayı
3
Künye
Kaya, K. Çiftçi, O. Çetin, A. Tecellioğlu, M. Başak, N. (2016). Beneficial effects of glucan against cisplatin side effects on the nervous system in rats 1. Acta Cir Brasl. 31 (3). 198-205.
